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A Novel Mouse Model of Prenatal Opioid Exposure

Award Number: R03DA051677
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2021
PERIOD OF PERFORMANCE END DATE: 03/31/2024

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A Novel Mouse Model of Prenatal Opioid Exposure - PROJECT SUMMARY/ABSTRACT Opioid use within the US has reached epidemic proportions, negatively impacting not just individuals and their families, but also communities. One of the most affected populations is pregnant women and their exposed offspring. Despite efforts to reduce access to prescription opioids, more potent, synthetic analogs such as fentanyl are becoming more readily available. Little is known of the long-term effects of fentanyl in exposed children. In this proposal, we will develop a clinically relevant mouse model of prenatal fentanyl exposure to determine the pharmacokinetic and functional (behavioral) profiles in exposed offspring. Developmental opioids are known to affect specific behavioral domains, and we will test offspring at both early (neonatal) and late (adult) ages. We hypothesize that fentanyl will diminish performance of behaviors related to drug reward and addiction, cognition, affect, social outcomes, and motor coordination. We further posit that the route and duration of exposure will exacerbate these deficiencies. This study will be the first to examine how long-term developmental fentanyl exposure alters both short- and long-term functional outcomes and will position us to determine the critical neural circuit changes underlying these altered phenotypes in order to develop therapeutic approaches in exposed children


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$1,881 )
2024	2022	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Drug Use and Addiction Research Programs	000	2	6/27/2024	NON-COMPETING CONTINUATION	-$1,881
														Subtotal = -$1,881

Issue Date FY: 2022 ( Subtotal = $77,000 )
2022	2022	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Drug Use and Addiction Research Programs	000	2	3/10/2022	NON-COMPETING CONTINUATION	$77,000
														Subtotal = $77,000

Issue Date FY: 2021 ( Subtotal = $77,000 )
2021	2021	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Drug Use and Addiction Research Programs	000	1	3/16/2021	NEW	$77,000
														Subtotal = $77,000

Grand Total All Awards = $152,119

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A Novel Mouse Model of Prenatal Opioid Exposure

Award Number: R03DA051677

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2021

PERIOD OF PERFORMANCE END DATE: 03/31/2024

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