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Archaea in African Americans with polyps

Award Number: R03CA277166
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/12/2022
PERIOD OF PERFORMANCE END DATE: 11/30/2024

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Archaea in African Americans with polyps - It is well-known that African Americans (AAs) face a higher risk and burden of colorectal cancer (CRC), but which genetic pathways or environmental/social determinants add to the risk of colorectal cancer are not well-known. Our overall working hypothesis is that the archaea in the human gut lumen are different in AAs compared to Non-Hispanic Whites (NHWs) and this difference (either in the numbers of archaea, types and/or function) contributes to the racial disparities observed in CRC. With this hypothesis, the study will use an existing sample set of AAs and NHWs with and without polyps. The first aim will determine M.Smithii and other archaea in AAs with and without polyps vs. NHWs with and without polyps using qPCR, amplicon and metagenomic sequencing. The second aim will examine genomic differences of M.smithii isolates from fecal samples of AAs with and without polyps vs NHWs with and without polyps. This will be the first study to examine archaea in the gut microbiome of AAs; and look at archaea diversity and functional potential in AAs with and without polyps and appropriate NHW controls, to understand CRC disparities in AAs. If differences are found similar to our preliminary data, manipulation of the archaea in AAs at risk for CRC can be considered, after further studies in larger cohorts.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $79,950 )
2024	2024	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Cancer Biology Research	000	2	11/27/2023	NON-COMPETING CONTINUATION	$79,950
														Subtotal = $79,950

Issue Date FY: 2023 ( Subtotal = $79,950 )
2023	2023	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Cancer Biology Research	000	1	12/12/2022	NEW	$79,950
														Subtotal = $79,950

Grand Total All Awards = $159,900

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Archaea in African Americans with polyps

Award Number: R03CA277166

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/12/2022

PERIOD OF PERFORMANCE END DATE: 11/30/2024

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