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Maternal acetaminophen use and childhood cancer

Award Number: R03CA273608
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2022
PERIOD OF PERFORMANCE END DATE: 10/31/2024

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Maternal acetaminophen use and childhood cancer - Project Summary/Abstract This proposal is responsive to NOT-OD-22-137: Availability of Administrative Supplements for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project. We aim to address Component 2: “Assembly of a large cohort of individuals with Down syndrome across the lifespan to perform deep phenotyping and study co-existing conditions.” We will build upon our large study of 2.3 million Taiwanese births, in which we are investigating maternal pharmaceutical intake in pregnancy and associations with childhood cancer; Aims of the parent study will not change. In the US, the population prevalence of Down syndrome (DS) is 250,000 persons, and 6000 children with DS are born in the US each year. Children with Down syndrome have a substantially increased risk for leukemia, and elevated risk for a number of other conditions. The proposed study will utilize data from a large cohort of Taiwanese children to examine comorbid conditions in children with Down syndrome. Participants in our study include all children born in Taiwan 2004-2015. Down syndrome and other diagnoses will be ascertained from the National Health Insurance Database in Taiwan. Results will be confirmed in a large cohort of Danish children. The goals of this project are to better understand comorbidities in Down syndrome to improve screening guidelines and management of patient care.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$118 )
2025	2023	UNIVERSITY OF NORTH TEXAS	1112 DALLAS DR STE 4000	DENTON	TX	76205	DENTON	USA	Cancer Cause and Prevention Research	001	2	3/20/2025	SUPPLEMENT FOR EXPANSION	-$41
2025	2023	UNIVERSITY OF NORTH TEXAS	1112 DALLAS DR STE 4000	DENTON	TX	76205	DENTON	USA	Cancer Cause and Prevention Research	000	2	3/20/2025	NON-COMPETING CONTINUATION	-$77
														Subtotal = -$118

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	UNIVERSITY OF NORTH TEXAS	1112 DALLAS DR STE 4000	DENTON	TX	76205	DENTON	USA	Cancer Cause and Prevention Research	000	2	2/7/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $89,033 )
2023	2023	UNIVERSITY OF NORTH TEXAS	1155 UNION CIR #305250	DENTON	TX	76203	DENTON	USA	Cancer Cause and Prevention Research	001	2	9/18/2023	SUPPLEMENT FOR EXPANSION	$31,045
2023	2023	UNIVERSITY OF NORTH TEXAS	1155 UNION CIR #305250	DENTON	TX	76203	DENTON	USA	Cancer Cause and Prevention Research	000	2	8/10/2023	NON-COMPETING CONTINUATION	$57,988
														Subtotal = $89,033

Issue Date FY: 2022 ( Subtotal = $70,086 )
2022	2022	UNIVERSITY OF NORTH TEXAS	1155 UNION CIR #305250	DENTON	TX	76203	DENTON	USA	Cancer Cause and Prevention Research	000	1	8/1/2022	NEW	$70,086
														Subtotal = $70,086

Grand Total All Awards = $159,001

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Maternal acetaminophen use and childhood cancer

Award Number: R03CA273608

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2022

PERIOD OF PERFORMANCE END DATE: 10/31/2024

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