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ISOFLAVONES, EQUOL PRODUCING STATUS, AND BREAST DENSITY IN US CHINESE WOMEN

Award Number: R03CA135689
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/16/2008
PERIOD OF PERFORMANCE END DATE: 06/30/2013

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ISOFLAVONES, EQUOL PRODUCING STATUS, AND BREAST DENSITY IN US CHINESE WOMEN - DESCRIPTION (provided by applicant): Isoflavones, phytoestrogens found primarily in soy foods, are thought to protect against breast cancer, but epidemiologic evidence for such an effect is inconsistent. Inter-individual variability in isoflavone metabolism might explain some of the inconsistent results. Between 20 and 60% of individuals have intestinal bacteria capable of metabolizing daidzein, one of the primary soy isoflavones, to equol. Equol has been observed in vitro to demonstrate stronger estrogenic and antioxidant properties than either its precursor or the other primary soy isoflavone, genistein. Because of its strong association with breast cancer, breast density is a useful marker for breast cancer risk. The proposed project will examine equol producing status in relation to breast density and evaluate whether the association between isoflavone intake and breast density differs by equol producing status in a unique cohort of US Chinese women. A secondary, more exploratory aim is to examine another daidzein metabolite, O-desmethylangolensin (O-DMA), in relation to breast density. The work will include 280 recently immigrated US Chinese women participating in a separately funded, longitudinal study on diet and breast density. Study participants are pre-/peri-menopausal, of mammography screening age, with US residence <=20 years. Data being collected for that study include questionnaires and dietary interviews, blood samples, and a screening mammogram examined for breast density. The proposed work will add collection of overnight urine samples, laboratory analyses to define equol and O-DMA producing status, and statistical analyses to examine cross-sectional associations of equol and O-DMA producing status and dietary isoflavones with breast density measures already being collected as part of the diet-breast density study.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $0 )
2013	2009	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	2	10/25/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $0 )
2011	2009	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	2	6/15/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2009	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	2	10/19/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2009 ( Subtotal = $87,250 )
2009	2009	FOX CHASE CANCER CENTER	333 Cottman Ave	Philadelphia	PA	19111	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	2	5/4/2009	NON-COMPETING CONTINUATION	$87,250
2009	2009	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Cause and Prevention Research	001	2	10/19/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $87,250

Issue Date FY: 2008 ( Subtotal = $86,750 )
2008	2008	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	1	7/16/2008	NEW	$86,750
														Subtotal = $86,750

Grand Total All Awards = $174,000

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ISOFLAVONES, EQUOL PRODUCING STATUS, AND BREAST DENSITY IN US CHINESE WOMEN

Award Number: R03CA135689

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/16/2008

PERIOD OF PERFORMANCE END DATE: 06/30/2013

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