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Examining endothelial cell and its plasticity in intramembranous bone regeneration

Award Number: R03AR082927
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2024
PERIOD OF PERFORMANCE END DATE: 09/30/2026

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Examining endothelial cell and its plasticity in intramembranous bone regeneration - Project Summary/Abstract: Intramembranous bone regeneration is a carefully orchestrated process of hematoma formation, inflammation, and blood vessel formation and invasion, which are necessary for bone to form. Among these, a lack of proper blood vessel formation and invasion has been identified as one of the factors leading to a failure of orthopaedic, dental, or biomimetic implant placements, all of which are dependent on the success of intramembranous bone regeneration. Therefore, the goal of this proposal is to gain enhanced understanding of vasculogenic or angiogenic processes that occur during intramembranous bone regeneration and explore the endothelial cell plasticity that could lead to novel therapeutic opportunities for several orthopaedic or dental procedures. The current knowledge and preliminary studies for this proposal indicate that both vasculogenesis (new blood vessel formation in the absence of vascular template) and angiogenesis (new blood vessel formation by sprouting from existing blood vessels) occur during intramembranous bone regeneration. Also, endothelial cells exhibit plasticity where the cells undergo endothelial-to-mesenchymal transition (EndMT) within the regenerating bone. Thus, these novel findings set the scientific premise to the central hypothesis that EndMT is integral to intramembranous bone regeneration. To address this hypothesis, we propose to determine the role of EndMT during vasculogenesis and angiogenesis in intramembranous bone regeneration by 1) examining EndMT of fluorescently labeled endothelial cells and 2) determining the effect of EndMT inhibition on regenerating bone. Successful completion of the proposed studies will provide novel insights regarding the role of EndMT in intramembranous bone regeneration that can lead to therapeutic opportunities to enhance orthopaedic and dental care.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	3/26/2026	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $158,000 )
2024	2024	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	3/21/2024	NEW	$158,000
2024	2024	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	1	7/11/2024	NEW	$0
														Subtotal = $158,000

Grand Total All Awards = $158,000

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Examining endothelial cell and its plasticity in intramembranous bone regeneration

Award Number: R03AR082927

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2024

PERIOD OF PERFORMANCE END DATE: 09/30/2026

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