Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Mitochondrial solute carriers on phagosomes in dendritic cells

Award Number: R03AI202317
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/03/2026
PERIOD OF PERFORMANCE END DATE: 06/30/2028

Group Awards By:

View Award Description

Mitochondrial solute carriers on phagosomes in dendritic cells - Summary Inter-organellar communication, the process by which different organelles in a cell communicate and coordinate their activities, is increasingly recognized as an essential process to maintain cellular homeostasis and support immune defense. Notably, mitochondria interactions with phagosomes promote bacterial killing in macrophages and neutrophils via mitochondrial radical oxygen species. However, the molecular machinery that supports this process is largely unknown. In addition, the characteristics and impact of mitochondria-phagosome communication in dendritic cells (DCs), the most efficient antigen (Ag) presenting cells and key linkers between innate and adaptive immune responses, remain unknown. After phagocytosis, phagosomes mature through interactions with the endo-lysosomal system. Phagosomes thereby acquire endosomal pattern recognition receptors (PRRs) like Toll-like receptors (TLRs), which promote phagocytosis-associated immune pathways, and lysosomal solute carrier transporters (SLCs), which facilitate metabolite transport. As phagosomes interact with the endo-lysosomal system, it is conceivable that players in lysosome-mitochondria interactions are also found on phagosomes. Specifically, both the formation of membrane contact sites (MCSs) – by which organellar membranes are maintained at close proximity via tether proteins – and the formation of mitochondria-derived vesicles (MDVs) have been proposed for lysosome- mitochondria crosstalk. In addition, it is possible that mechanisms that promote phagosome interactions with the endo-lysosomal system, such as PRR stimulation, also promote mitochondria-phagosome communication. Notably, we have found that some mitochondrial SLCs (mito-SLCs) are recruited to phagosomes during maturation. Based on our and others’ observations, we hypothesize that: i. PRR-dependent signaling upon phagocytosis in DCs promotes mitochondria-phagosome crosstalk via MCSs or MDVs to recruit mitochondrial SLCs to phagosomes; ii. mito-SLC function supports phagosome-associated immune responses other than direct bacterial killing in DCs, such as pro-inflammatory cytokine production and Ag presentation. We will test these hypotheses with the following Specific Aims: Aim 1. To determine how mitochondria and mito-SLCs are recruited to phagosomes in DCs. We will determine whether mito-SLC recruitment to phagosomes: 1) depends on phagosome-mitochondria contact sites and/ or MDV fusion; and 2) is promoted by PRR signaling. Aim 2. To determine whether mito-SLCs promote phagosomal signaling in DCs. We will determine whether (1) mito-SLCs promote the production of pro-inflammatory cytokines and Ag presentation after phagocytosis; (2) this effect is mediated by TLR- or other solute-depending signaling; and 3) mito-SLC phagosomal functions require mitochondria recruitment to phagosomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $78,500 )
2026	2026	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST STE 1	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	000	1	7/7/2026	NEW	$78,500
														Subtotal = $78,500

Grand Total All Awards = $78,500

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Mitochondrial solute carriers on phagosomes in dendritic cells

Award Number: R03AI202317

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/03/2026

PERIOD OF PERFORMANCE END DATE: 06/30/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer