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HIV Targeting of IPS-1/MAVS to Block Type I Interferon

Award Number: R03AI194999
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/19/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2028

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HIV Targeting of IPS-1/MAVS to Block Type I Interferon - Project Summary/Abstract Over the course of infection by HIV, a dynamic interplay occurs between the HIV and the human immune system. HIV is an immune cell-tropic virus, infecting both CD4+ T helper cells as well as macrophages which also express CD4 in humans. Infection of these two different, key immune cells sets up a scenario that allows modulation of the immune system coupled with the pathology of the viral infection. In fact, successful replication and pathogenesis of any virus within a human host is dependent on how well the virus is able to manipulate the many defenses of the immune system and in this case, the cells HIV infects. One of the main targets of this manipulation of human immunity by viral infections is the Type I Interferon system. Our group has focused on modulation of the Type I Interferons by the accessory proteins of HIV that are used by HIV to promote viral replication within a human. We showed that both Nef and Vpu are able to target both the production of and signaling by Type I Interferon pathways within T cells allowing improved replication of HIV. In this proposal we will investigate how HIV manipulates the interferon (IFN) system to evade immune detection and persist in the host. This R03’s specific aim is to determine the mechanism by which HIV accessory proteins Vpu and Nef target IPS-1, a key adaptor protein for IFN induction, leading to its degradation and inhibiting IFN production and to confirm that this mechanism is consistent in HIV infection of multiple cell types.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $144,000 )
2026	2026	WESTERN UNIVERSITY OF HEALTH SCIENCES	309 E 2ND ST	POMONA	CA	91766	LOS ANGELES	USA	Allergy and Infectious Diseases Research	000	1	6/30/2026	NEW	$144,000
														Subtotal = $144,000

Grand Total All Awards = $144,000

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HIV Targeting of IPS-1/MAVS to Block Type I Interferon

Award Number: R03AI194999

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/19/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2028

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