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Chlamydia trachomatis modulation of host inflammasome

Award Number: R03AI185821
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Chlamydia trachomatis modulation of host inflammasome - Chlamydia trachomatis is the leading cause of sexually transmitted infections worldwide with approximately 90 million new cases reported annually. Complications to infection in women include pelvic inflammatory disease, ectopic pregnancy and increased risk of cervical cancer. Despite these significant medical concerns there are fundamental gaps in our understanding of Chlamydia pathogenesis, particularly with regards to the host immune response and inflammasome activation. C. trachomatis is known to stimulate IL-1beta secretion and activate the NLRP3 inflammasome but the mechanism of modulation is not known. Our strong preliminary data demonstrates that a Chlamydial protein, CT226, interacts with Leucine Rich Repeat Protein 1 (LRRFIP1), and Flightless 1 (FLII), upstream regulators of the NLRP3 inflammasome. We hypothesize that this interaction between CT226 and LRRFIP1/FLII modulates inflammasome activation during C. trachomatis infection. With the latest innovative genetic tools and transformation methods, we have generated a CT226 deletion strain of C. trachomatis. The CT226 deletion mutant will be assessed for differences in inflammasome activation, secretion of 1L-1beta, IL-18 and caspase 1 activation. Using siRNA depletion and inflammasome deficient cell lines we will assess the role of inflammasome activation on C. trachomatis replication, infectivity and intracellular survival. The proposed research is critical to understanding the role inclusion membrane proteins have in host immune response during C. trachomatis infections and will address a key fundamental knowledge gap regarding Chlamydia modulation of inflammasome activation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $145,745 )
2025	2025	OKLAHOMA STATE UNIVERSITY	401 WHITEHURST HALL	STILLWATER	OK	74078	PAYNE	USA	Allergy and Infectious Diseases Research	000	1	7/23/2025	NEW	$145,745
														Subtotal = $145,745

Grand Total All Awards = $145,745

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Chlamydia trachomatis modulation of host inflammasome

Award Number: R03AI185821

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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