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Pan Coronavirus Genomic Surveillance of a Large NHP Colony

Award Number: R03AI174152
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 11/14/2022
PERIOD OF PERFORMANCE END DATE: 10/31/2024

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Pan Coronavirus Genomic Surveillance of a Large NHP Colony - Project Summary/Abstract The novel coronavirus that emerged in late 2019, termed SARS-CoV-2, quickly spread throughout the world and has killed millions. A critical aspect of this pandemic that remains understudied is the impact of immunity to seasonal coronaviruses on COVID-19 disease. Several lines of evidence suggest there is an impact but the nature of that impact remains unclear. We have preliminary data confirming our colony of 5,000 rhesus macaques harbors a large fraction of animals with preexisting immunity to coronaviruses of unknown origin. This immunity may be important in the use of these animals for COVID-19 and other coronavirus disease. We hypothesize that our colony seasonally circulates human seasonal coronaviruses but we need to identify the actual viruses circulating. Here, we will use multiple approaches to assess the frequency of these infections and to identify the actual viruses. In Aim 1, we will use pan-coronavirus primers to quantify coronavirus infections in our colony. We will sample both nasal and rectal sites as coronaviruses are known to be shed from both. In Aim 2, we will use next generation sequencing to identify the viruses circulating. We will apply phylogenetic approaches to characterize the diversity of the virus or viruses in our colony. These data will have important implications for the use of macaques for coronavirus infections in general and may shed light on the coronavirus family.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $87,500 )
2024	2024	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Allergy and Infectious Diseases Research	000	2	10/26/2023	NON-COMPETING CONTINUATION	$78,750
2024	2024	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Allergy and Infectious Diseases Research	001	2	5/10/2024	NON-COMPETING CONTINUATION	$8,750
														Subtotal = $87,500

Issue Date FY: 2023 ( Subtotal = $87,500 )
2023	2023	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Allergy and Infectious Diseases Research	000	1	11/14/2022	NEW	$87,500
														Subtotal = $87,500

Grand Total All Awards = $175,000

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Pan Coronavirus Genomic Surveillance of a Large NHP Colony

Award Number: R03AI174152

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 11/14/2022

PERIOD OF PERFORMANCE END DATE: 10/31/2024

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