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Mitochondrial RNA as a proinflammatory mediator

Award Number: R03AI168677
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/14/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Mitochondrial RNA as a proinflammatory mediator - Inflammation is implicated in a wide range of disorders and thought to be involved in most leading causes of death today in the United States with high associated costs. New insights into better understanding its etiology, detection and prevention are thus of major importance in health care. This has been achieved in part through the recent discovery of proinflammatory DAMPs, including mitochondrial DNA (mtDNA). However, little is known about the proinflammatory effects of the other major mitochondrial nucleic acid, mtRNA. Here, we propose to fill this gap by extending our recent mtRNA studies and assessing therapeutic targets. These studies are a major extension of a previously small literature on mtRNA immunostimulation, and provide new insights into the role of native and oxidized mtRNA in inflammation as a result of their inappropriate release to the cytoplasm and extracellular milieu including blood. Specifically, we propose to test the hypothesis that both native and oxidized mtRNAs are important inflammatory mediators with diagnostic and treatment potential. Here, we will characterize the mechanistic basis underlying the proinflammatory activity of mitochondrial RNA (mtRNA); determine the mechanistic effect of oxidation on mtRNA immunostimulation; and assess the immunostimulatory activity and associated structural forms of mtRNA in human plasma. The overall goal is to better understand the role of both native and oxidized forms of mtRNA in inflammation, and to eventually exploit this information toward the diagnosis and treatment of excessive mtRNA release-related inflammatory pathologies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	ALBANY MEDICAL COLLEGE	47 NEW SCOTLAND AVE # A34	ALBANY	NY	12208	ALBANY	USA	Allergy and Infectious Diseases Research	000	2	5/1/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $81,500 )
2023	2023	ALBANY MEDICAL COLLEGE	47 NEW SCOTLAND AVE	ALBANY	NY	12208	ALBANY	USA	Allergy and Infectious Diseases Research	000	2	5/1/2023	NON-COMPETING CONTINUATION	$81,500
														Subtotal = $81,500

Issue Date FY: 2022 ( Subtotal = $81,500 )
2022	2022	ALBANY MEDICAL COLLEGE	47 NEW SCOTLAND AVE	ALBANY	NY	12208	ALBANY	USA	Allergy and Infectious Diseases Research	000	1	6/14/2022	NEW	$81,500
														Subtotal = $81,500

Grand Total All Awards = $163,000

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Mitochondrial RNA as a proinflammatory mediator

Award Number: R03AI168677

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/14/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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