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STnc520, a virulence-associated regulatory RNA in Salmonella Typhimurium

Award Number: R03AI150987
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2020
PERIOD OF PERFORMANCE END DATE: 11/30/2024

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STnc520, a virulence-associated regulatory RNA in Salmonella Typhimurium - SUMMARY Salmonella enterica serovar Typhimurium is a major cause of foodborne illness in the USA and worldwide. During the initial stages of infection, S. Typhimurium invades gut epithelial cells. Expression of genes required for invasion is controlled by a group of transcription factors encoded with the SPI-1 pathogenicity island. We have recently mapped the regulatory targets of these transcription factors. The majority of the regulatory interactions we identified have not been previously described. Thus, the regulatory network associated with invasion is considerably more complex than previously appreciated. Moreover, our work strongly suggests an important role for regulatory RNAs during invasion. Of particular interest is the regulatory RNA STnc520, whose expression is coordinated with that of other invasion genes, and which has been suggested to be important for establishing an infection in three animal models, based on data from high-throughput transposon screens. Here, we will determine the requirement for STnc520 for S. Typhimurium to invade epithelial cells, both in vitro and in vivo. We will also identify direct regulatory targets of STnc520. Thus, we will establish the role of STnc520 during invasion, laying the foundation for future studies of this and other regulatory RNAs that promote invasion.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	HEALTH RESEARCH, INC.	150 BROADWAY STE 280	MENANDS	NY	12204	ALBANY	USA	Allergy and Infectious Diseases Research	000	2	4/15/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	HEALTH RESEARCH, INC.	150 BROADWAY STE 280	MENANDS	NY	12204	ALBANY	USA	Allergy and Infectious Diseases Research	000	2	11/27/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $83,100 )
2022	2022	HEALTH RESEARCH, INC.	EMPIRE STATE PLAZA	ALBANY	NY	12237	ALBANY	USA	Allergy and Infectious Diseases Research	000	2	12/16/2021	NON-COMPETING CONTINUATION	$83,100
														Subtotal = $83,100

Issue Date FY: 2021 ( Subtotal = $82,616 )
2021	2021	HEALTH RESEARCH, INC.	EMPIRE STATE PLAZA	ALBANY	NY	12237	ALBANY	USA	Allergy and Infectious Diseases Research	000	1	11/24/2020	NEW	$82,616
														Subtotal = $82,616

Grand Total All Awards = $165,716

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STnc520, a virulence-associated regulatory RNA in Salmonella Typhimurium

Award Number: R03AI150987

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2020

PERIOD OF PERFORMANCE END DATE: 11/30/2024

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