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NOVEL 2'- AND 3'- BRANCHED CARBOCYCLIC NUCLEOSIDES WILL BE SYNTHESIZED AND EVALUA

Award Number: R03AI088542
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/23/2010
PERIOD OF PERFORMANCE END DATE: 08/31/2012

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NOVEL 2'- AND 3'- BRANCHED CARBOCYCLIC NUCLEOSIDES WILL BE SYNTHESIZED AND EVALUA - DESCRIPTION (provided by applicant): The emergence of new viral diseases such as HCV, SARS, West Nile virus, H1N1 influenza, increased threat of bioterrorism using smallpox and appearance of new viral strains resistant to existing drugs warrants development of new medications. The goal of this proposal is to discover new antiviral candidates to treat such diseases by modifying a lead carbocyclic nucleoside analog. New analogs synthesized will be tested for antiviral activity against a wide array of viruses. PUBLIC HEALTH RELEVANCE: The goal of this proposal is to discover new antiviral candidates to treat new viral diseases such as HCV, SARS, West Nile virus, H1N1 influenza, and bioterrorism agent smallpox. The proposed research project also focuses on the development of new medications to viral strains resistant to existing drugs by modifying a lead carbocyclic nucleoside analog.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2011 ( Subtotal = $103,455 )
2011	2011	ORGANIX, INC	240 SALEM STREET	WOBURN	MA	01801	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	2	7/29/2011	NON-COMPETING CONTINUATION	$103,455
														Subtotal = $103,455

Issue Date FY: 2010 ( Subtotal = $104,500 )
2010	2010	ORGANIX, INC	240 SALEM STREET	WOBURN	MA	01801	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	1	9/21/2010	NEW	$104,500
														Subtotal = $104,500

Grand Total All Awards = $207,955

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NOVEL 2'- AND 3'- BRANCHED CARBOCYCLIC NUCLEOSIDES WILL BE SYNTHESIZED AND EVALUA

Award Number: R03AI088542

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/23/2010

PERIOD OF PERFORMANCE END DATE: 08/31/2012

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