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Deep phenotyping and genotypic risk in presymptomatic family members of Frontotemporal dementia patients in India (D-PRIME-FTD)

Award Number: R03AG097670
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Deep phenotyping and genotypic risk in presymptomatic family members of Frontotemporal dementia patients in India (D-PRIME-FTD) - Deep phenotyping and genotypic risk in presymptomatic family members of Frontotemporal dementia patients in India (D-PRIME-FTD) Project Summary/Abstract Frontotemporal dementia (FTD) is a neurodegenerative disorder marked by behavioral, language, and motor changes, associated with degeneration of frontal and temporal lobes, [Frontotemporal lobar degeneration (FTLD)]. Its presentation often overlaps with symptoms seen in psychiatric conditions. FTLD is highly heritable, with 20% linked to mutations in C9orf72, GRN and MAPT genes. Early identification of FTLD is crucial for clinical trials targeting preclinical stages, where subtle cognitive and behavioral changes, alongside biomarkers such as brain volumes, and neurofilament light chain (NfL), precede symptoms. India’s diverse population offers a unique opportunity to expand FTLD research and enhance global trial readiness. Familial forms of FTLD, which account for up to 40% of cases, provide an opportunity to study early disease mechanisms through clinical and genetic profiling. While large multinational studies have characterized presymptomatic FTLD in western populations, there is a critical gap in understanding its trajectory in diverse populations like India. This proposed study aims to establish a group of well-characterized high-risk presymptomatic relatives of FTLD families in India, using deep phenotyping, genetics, serum biomarkers, and advanced brain imaging. By identifying these multimodal markers in ≈300 presymptomatic family members, we will unravel early indicators of disease progression and stratify individuals based on genetic risk and presymptomatic status. This comprehensive approach will provide insights into the disease trajectory, and enhance clinical trial readiness, contributing to the development of targeted therapies and biomarker-driven interventions for FTLD in the Indian populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $215,961 )
2026	2026	NATIONAL INSTITUTE OF MENTAL HEALTH AND NEURO SCIENCES	HOSUR ROAD	BANGALORE				IND	Aging Research	000	1	8/27/2026	NEW	$215,961
														Subtotal = $215,961

Grand Total All Awards = $215,961

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Deep phenotyping and genotypic risk in presymptomatic family members of Frontotemporal dementia patients in India (D-PRIME-FTD)

Award Number: R03AG097670

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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