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Prospective Memory in Everyday Life: Lapses and Decline in Relation to Inflammatory and Neurodegenerative Biomarkers in Older Adults

Award Number: R03AG081565
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2023
PERIOD OF PERFORMANCE END DATE: 11/30/2025

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Prospective Memory in Everyday Life: Lapses and Decline in Relation to Inflammatory and Neurodegenerative Biomarkers in Older Adults - PROJECT SUMMARY Prospective memory (PM) refers to memory for future intentions, such as attending an appointment or taking medication. Research suggests that, compared to other cognitive measures, PM deficits can better distinguish healthy older adults from those with mild cognitive impairment or in early stages of dementia. However, limited work has examined PM and biological correlates of pathological memory decline, such as inflammatory and neurodegenerative biomarkers. The proposed project will use unanalyzed data existing within the Einstein Aging Study (EAS) to examine older adults’ everyday PM lapses in association with markers of inflammation (Aim 1) and neurodegeneration (Aim 2) at cross-section and longitudinally. Analyses will also address the moderating effect of gender/sex in the proposed links between PM, inflammation, and neurodegeneration (Aim 3). Findings from the proposed project will advance our understanding of the biological underpinnings of PM. Additionally, findings will provide valuable insight into biological conditions related to inflammation and neurodegeneration that may explain when PM declines are indicative of cognitive impairment, as well as whether the hypothesized relationships differ by gender/sex.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $158,231 )
2025	2025	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE	LARAMIE	WY	82071	ALBANY	USA	Aging Research	002	3	4/28/2025	NON-COMPETING CONTINUATION	$15,823
2025	2025	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE	LARAMIE	WY	82071	ALBANY	USA	Aging Research	000	3	11/26/2024	NON-COMPETING CONTINUATION	$142,409
2025	2023	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Aging Research	001	1	1/31/2025	NEW	-$1
														Subtotal = $158,231

Issue Date FY: 2024 ( Subtotal = -$14,568 )
2024	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Aging Research	002	2	12/19/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$132,399
2024	2023	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Aging Research	001	1	12/15/2023	NEW	$1
2024	2023	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Aging Research	000	1	12/14/2023	NEW	-$146,968
														Subtotal = -$14,568

Issue Date FY: 2023 ( Subtotal = $160,400 )
2023	2023	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Aging Research	000	1	5/9/2023	NEW	$160,400
														Subtotal = $160,400

Grand Total All Awards = $304,063

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Prospective Memory in Everyday Life: Lapses and Decline in Relation to Inflammatory and Neurodegenerative Biomarkers in Older Adults

Award Number: R03AG081565

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2023

PERIOD OF PERFORMANCE END DATE: 11/30/2025

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