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Quantitative proteomic analysis of the aging brain after intracerebral hemorrhage

Award Number: R03AG077460
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Quantitative proteomic analysis of the aging brain after intracerebral hemorrhage - Intracerebral hemorrhage (ICH) is a devastating subtype of stroke with no effective treatment. Lack of treatment options partly contributes to the poorly defined pathophysiology of ICH. Along these lines, despite the increasing prevalence of ICH in the elderly, the molecular level changes that occur in the aging brain after ICH remains largely enigmatic. To address this critical knowledge gap, two specific aims are proposed. Aim 1: To determine the age-induced changes in the brain proteome after ICH. Aim 2: To determine the age-induced protein level changes in microglia and brain-infiltrating monocyte-derived macrophages (BMDM) after ICH. The proposed studies employ a preclinical model of ICH and include unbiased and rigorous proteomics approaches such as label-free and TMT-labeling Mass spectrometry and bioinformatics approaches. Successful completion of the project would identify novel molecular regulators to improve the neurological outcomes after ICH in the elderly. Also, the studies would define, for the first time, the proteomic profile of acutely isolated microglia and macrophages, the cells that play key roles in brain damage and repair after ICH.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$198 )
2026	2023	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC	AUGUSTA UNIVERSITY 1120 15TH STREET	AUGUSTA	GA	30912	RICHMOND	USA	Aging Research	000	2	12/8/2025	NON-COMPETING CONTINUATION	-$198
														Subtotal = -$198

Issue Date FY: 2023 ( Subtotal = $77,000 )
2023	2023	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.	1120 15TH ST STE CJ3301	AUGUSTA	GA	30912	RICHMOND	USA	Aging Research	000	2	6/30/2023	NON-COMPETING CONTINUATION	$77,000
														Subtotal = $77,000

Issue Date FY: 2022 ( Subtotal = $77,000 )
2022	2022	AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.	1120 15TH ST STE CJ3301	AUGUSTA	GA	30912	RICHMOND	USA	Aging Research	000	1	9/22/2022	NEW	$77,000
														Subtotal = $77,000

Grand Total All Awards = $153,802

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Quantitative proteomic analysis of the aging brain after intracerebral hemorrhage

Award Number: R03AG077460

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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