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Racial/Ethnic Disparities in the Alzheimer's Disease Link with Heart Disease and Stroke

Award Number: R03AG075034
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2022
PERIOD OF PERFORMANCE END DATE: 01/31/2025

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Racial/Ethnic Disparities in the Alzheimer's Disease Link with Heart Disease and Stroke - Abstract: Alzheimer’s disease (AD) is the major subtype of dementia, which accounts for 60-80% of dementia cases in the United States (US). With the increased life expectancy in developed countries, AD is becoming a major issue at the late stage of life. Heart disease and stroke events are another two growing issues among the elderly population. There is an expanding body of literature implicating heart disease and stroke as risk factors for AD, highlighting significant pathways at the cellular level. However, further research is needed on the association between heart, stroke, and development of AD to improve our understanding of epidemiological features of this link, which could lead us to identify high-risk subgroups who potentially disadvantaged from such dependencies. Hawaii's population is one of the most diverse ethnic populations in the US and there exist significant racial/ethnic health disparities in this multiethnic population. Especially, Native Hawaiians and Pacific Islanders (NHPI) are a well-known high-risk group for many disease conditions, including cardiovascular conditions and stroke. Links between heart dysfunction and stroke on developing AD makes NHPI potentially a high-risk group for AD. We propose a study to explore the AD risk for patients age 65 and above those who had major heart events and stroke, based on the Hawaii Medicare database. The proposed work will be conducted under a time-to-event multistate model framework while accounting for competing risks for acquiring unbiassed estimations and inferencing. Nine years of Hawaii Medicare data from 2009 to 2017 will be utilized to gather important time-to-event details for the proposed work, which allows us to conduct comprehensive time-to-event analyses on several aspects: progression from heart disease or stroke to AD; AD mortality; heart disease and stroke risks for AD. A key feature of the proposed study is the investigation of racial/ethnic dependency on AD, heart disease, and stroke links. We also propose to develop machine learning-driven predictive models for predicting transitions and mortality based on subject profiles.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$15 )
2025	2023	UNIVERSITY OF HAWAII	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Aging Research	000	2	5/27/2025	NON-COMPETING CONTINUATION	-$15
														Subtotal = -$15

Issue Date FY: 2023 ( Subtotal = $157,212 )
2023	2023	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Aging Research	000	2	1/30/2023	NON-COMPETING CONTINUATION	$157,212
														Subtotal = $157,212

Issue Date FY: 2022 ( Subtotal = $157,002 )
2022	2022	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Aging Research	000	1	1/31/2022	NEW	$157,002
														Subtotal = $157,002

Grand Total All Awards = $314,199

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Racial/Ethnic Disparities in the Alzheimer's Disease Link with Heart Disease and Stroke

Award Number: R03AG075034

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2022

PERIOD OF PERFORMANCE END DATE: 01/31/2025

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