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In vivo staging of preclinical Alzheimer's disease progression

Award Number: R03AG060263
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2018
PERIOD OF PERFORMANCE END DATE: 05/31/2021

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In vivo staging of preclinical Alzheimer's disease progression - PROJECT SUMMARY/ABSTRACT The social, economic and personal burden of Alzheimer's disease (AD) is rapidly climbing in the U.S. with diagnoses expected to more than double over the next three decades. At the same time, our understanding of the brain changes associated with AD is increasing exponentially, and promising interventions to slow or halt the progress of the disease are beginning to move from the laboratory into the clinic. In this context, the development of approaches to aid early detection of the transition from healthy aging to mild cognitive impairment (MCI) and AD is becoming critically important. The Alzheimer's Disease Neuroimaging Initiative (ADNI), funded by the National Institutes of Aging and Bioimaging and Bioengineering, was launched in 2005 to provide a large database data to develop diagnostic and prognostic biomarkers of AD. While the overarching goal of this longitudinal data collection initiative is to provide information and methods leading to effective treatment and prevention of AD, the significant promise of in vivo neuroimaging in this area has yet to be fully realized. However, we can now reliably detect AD in humans based on biological markers, sometimes decades before cognitive symptoms emerge based upon cerebrospinal fluid (CSF) concentrations of the amyloid beta peptide 1-42 (Aβ) The advent of the CSF Aβ biomarker opens a window for studying the pathological progression of AD at preclinical stages of disease in humans. We will capitalize on the rich array of multi-modal data available through the ADNI to integrate structural MRI and gene expression data, in combination with the CSF Aβ biomarker, to (i) identify cell-type specific degeneration of the cholinergic basal forebrain neurons across preclinical and mild cognitive impairment stages of AD, and (ii) map the subcortical-to-cortical spread of cholinergic degeneration by examining the covariance of structural degeneration between the basal forebrain and cortex.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $1 )
2023	2019	ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL	845 RUE SHERBROOKE O	MONTREAL	PQ			CAN	Aging Research	000	2	11/23/2022	NON-COMPETING CONTINUATION	$1
														Subtotal = $1

Issue Date FY: 2022 ( Subtotal = -$1 )
2022	2019	ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL	845 RUE SHERBROOKE O	MONTREAL	PQ			CAN	Aging Research	000	2	12/9/2021	NON-COMPETING CONTINUATION	-$1
														Subtotal = -$1

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL	845 RUE SHERBROOKE O	MONTREAL	PQ	H3A 0G4		CAN	Aging Research	000	2	6/15/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $52,255 )
2019	2019	ROYAL INSTITUTE FOR ADVANCEMENT OF LEARNING MCGILL	845 SHERBROOKE STREET WEST	MONTREAL	PQ	H3A 0G4		CAN	Aging Research	000	2	5/28/2019	NON-COMPETING CONTINUATION	$52,255
														Subtotal = $52,255

Issue Date FY: 2018 ( Subtotal = $53,956 )
2018	2018	ROYAL INSTITUTE FOR ADVANCEMENT OF LEARNING MCGILL	845 SHERBROOKE STREET WEST	MONTREAL	PQ	H3A 0G4		CAN	Aging Research	000	1	8/8/2018	NEW	$53,956
														Subtotal = $53,956

Grand Total All Awards = $106,211

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In vivo staging of preclinical Alzheimer's disease progression

Award Number: R03AG060263

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2018

PERIOD OF PERFORMANCE END DATE: 05/31/2021

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