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BioGRID: An open resource for biological interaction data and disease network analysis

Award Number: R01OD010929
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2007
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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BioGRID: An open resource for biological interaction data and disease network analysis - Abstract/Summary Understanding the complex molecular networks that regulate human health and disease remains a central challenge in biomedical research. Despite decades of research and the rapid advances of high-throughput technologies that generate vast amounts of data, most information about the interactions that underpin these networks remains locked in millions of publications in unstructured formats that are not amenable to computational analysis or artificial intelligence (AI)-driven discovery. BioGRID has addressed this gap as an open-access repository of genetic, protein and chemical interactions curated from the primary literature. The BioGRID currently contains over 2.8 million documented interactions from over 87,320 publications, and averages 151,907 page views and 17,753 unique visitors per month. The BioGRID companion resource, the Online Repository of CRISPR Screens (ORCS), contains data for over 2,200 CRISPR screens that report gene-phenotype relationships. This renewal proposes an ambitious expansion of BioGRID, with four major deliverables. First, we will undertake comprehensive curation of the human literature through AI-assisted pipelines that combine large language models (LLMs) and other ML approaches with expert curator validation to accelerate extraction of protein, genetic, and chemical interactions. Second, we will significantly expand themed curation projects, focusing on NIH priority areas, including autism, pediatric obesity and insulin resistance, and the druggable genome. For themed projects, we will also capture the rich contextual metadata, such as tissue specificity, isoforms, and genetic variants, that are valuable for precision medicine and AI applications. Third, we will develop BioGRID SPARK, a dedicated resource for synthetic protein annotation and interaction data, to address a rapidly emerging frontier in synthetic biology and therapeutic design. Finally, we will implement BioGRID Explorer, a conversational AI-driven search platform that will empower users and further enhance data accessibility. Our proposal will position BioGRID as a foundational resource for biomedical research and a critical engine for AI-enabled biomedical discovery.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $968,116 )
2026	2026	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON			CAN	Research Infrastructure Programs	002	20	7/17/2026	COMPETING CONTINUATION	$968,116
2026	2025	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON			CAN	Research Infrastructure Programs	001	19	7/14/2026	NON-COMPETING CONTINUATION	$0
2026	2025	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON			CAN	Research Infrastructure Programs	000	19	5/19/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $968,116

Issue Date FY: 2025 ( Subtotal = $939,919 )
2025	2025	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON			CAN	Research Infrastructure Programs	000	19	6/28/2025	NON-COMPETING CONTINUATION	$939,919
														Subtotal = $939,919

Issue Date FY: 2024 ( Subtotal = $939,919 )
2024	2024	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON			CAN	Research Infrastructure Programs	003	18	6/26/2024	NON-COMPETING CONTINUATION	$939,919
2024	2023	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON			CAN	Research Infrastructure Programs	002	17	2/27/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,082,248
2024	2022	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON			CAN	Research Infrastructure Programs	001	16	2/27/2024	SUPPLEMENT FOR EXPANSION	-$295,621
2024	2022	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON			CAN	Research Infrastructure Programs	000	16	2/27/2024	NON-COMPETING CONTINUATION	-$786,628
														Subtotal = $939,919

Issue Date FY: 2023 ( Subtotal = $939,919 )
2023	2023	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON			CAN	Research Infrastructure Programs	001	17	6/13/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$939,919
2023	2022	REDACTED DUE TO PII		TORONTO	ON			CAN	Research Infrastructure Programs	000	16	6/13/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $939,919

Issue Date FY: 2022 ( Subtotal = $1,293,148 )
2022	2022	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON			CAN	Research Infrastructure Programs	003	16	7/7/2022	SUPPLEMENT FOR EXPANSION	$353,229
2022	2022	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON			CAN	Research Infrastructure Programs	002	16	7/6/2022	NON-COMPETING CONTINUATION	$939,919
2022	2021	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON			CAN	Research Infrastructure Programs	001	15	1/19/2022	COMPETING CONTINUATION	$263,458
2022	2020	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON			CAN	Research Infrastructure Programs	000	14	1/19/2022	NON-COMPETING CONTINUATION	-$263,458
														Subtotal = $1,293,148

Issue Date FY: 2021 ( Subtotal = $942,594 )
2021	2021	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON			CAN	Research Infrastructure Programs	001	15	7/7/2021	COMPETING CONTINUATION	$942,594
2021	2020	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON			CAN	Research Infrastructure Programs	000	14	7/6/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $942,594

Issue Date FY: 2020 ( Subtotal = $895,351 )
2020	2020	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Research Infrastructure Programs	000	14	5/20/2020	NON-COMPETING CONTINUATION	$895,351
														Subtotal = $895,351

Issue Date FY: 2019 ( Subtotal = $895,351 )
2019	2019	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Research Infrastructure Programs	001	13	6/6/2019	NON-COMPETING CONTINUATION	$895,351
2019	2015	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Research Infrastructure Programs	000	9	1/7/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $895,351

Issue Date FY: 2018 ( Subtotal = $895,351 )
2018	2018	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Research Infrastructure Programs	000	12	7/16/2018	NON-COMPETING CONTINUATION	$895,351
														Subtotal = $895,351

Issue Date FY: 2017 ( Subtotal = $850,582 )
2017	2017	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Research Infrastructure Programs	000	11	6/1/2017	NON-COMPETING CONTINUATION	$805,815
2017	2017	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Research Infrastructure Programs	001	11	9/11/2017	NON-COMPETING CONTINUATION	$44,767
														Subtotal = $850,582

Issue Date FY: 2016 ( Subtotal = $895,351 )
2016	2016	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Research Infrastructure Programs	001	10	6/2/2016	COMPETING CONTINUATION	$895,351
2016	2015	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Research Infrastructure Programs	000	9	5/31/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $895,351

Issue Date FY: 2015 ( Subtotal = $860,238 )
2015	2015	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Research Infrastructure Programs	000	9	2/26/2015	NON-COMPETING CONTINUATION	$860,238
														Subtotal = $860,238

Issue Date FY: 2014 ( Subtotal = $877,795 )
2014	2014	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Research Infrastructure Programs	002	8	6/7/2014	NON-COMPETING CONTINUATION	$877,795
2014	2013	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Research Infrastructure Programs	001	7	5/7/2014	EXTENSION WITH OR WITHOUT FUNDS	$834,783
2014	2013	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Research Infrastructure Programs	000	7	5/6/2014	EXTENSION WITH OR WITHOUT FUNDS	-$834,783
														Subtotal = $877,795

Issue Date FY: 2013 ( Subtotal = $834,783 )
2013	2013	SAMUEL LUNENFELD RES INST	600 UNIVERSITY AVE	TORONTO ONTARTIO				CAN	Research Infrastructure Programs	000	7	2/11/2013	EXTENSION WITH OR WITHOUT FUNDS	$790,015
2013	2013	SAMUEL LUNENFELD RES INST	600 UNIVERSITY AVE	TORONTO ONTARTIO				CAN	Research Infrastructure Programs	001	7	6/15/2013	EXTENSION WITH OR WITHOUT FUNDS	$44,768
														Subtotal = $834,783

Issue Date FY: 2012 ( Subtotal = $877,795 )
2012	2012	SAMUEL LUNENFELD RES INST	600 UNIVERSITY AVE	TORONTO ONTARTIO				CAN	Research Infrastructure Programs	000	6	3/12/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$877,795
														Subtotal = $877,795

Grand Total All Awards = $13,906,212

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BioGRID: An open resource for biological interaction data and disease network analysis

Award Number: R01OD010929

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2007

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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