Monday, February 16, 2026 2/16/2026

Preparation for lung transplant discussions and decisions among people with cystic fibrosis

Award Number: R01NR020470
ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/19/2023
PERIOD OF PERFORMANCE END DATE: 01/31/2028

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Preparation for lung transplant discussions and decisions among people with cystic fibrosis - Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Cystic fibrosis (CF) is a progressive, fatal genetic condition (median age at death was 34 years in 2020). Lung transplant (LTx) is a treatment for end-stage CF and confers 10 years median survival for adults with CF. In the U.S., among CF patients with forced expiratory volume in 1 second (FEV1) less than 30% of predicted, more patients die each year than undergo LTx. More than half of CF patients who die without LTx are never referred for consideration. Patient preference may account for 25-40% of decisions to defer referral, but choices may at times be informed by inaccurate assumptions regarding LTx. CF patients with low FEV1 have high rates of anxiety and depression, which may contribute to avoidance of LTx conversations. Increasing LTx comprehension, and promoting the process of deliberation, could reduce the number of people with CF who die without LTx. We collaborated with CF patients, caregivers, and physicians to develop Take on Transplant (ToT): a web-based, patientfacing resource for LTx education. ToT shares personal narratives of CF patients and caregivers and up-to-date, CFspecific, guideline-based medical information about LTx. The overall research objectives are to test the efficacy of ToT compared to an attention control in a multicenter randomized clinical trial incorporating mixed methods to assess preparedness for LTx discussions among all CF patients with FEV1 <50% predicted, explore the impact of ToT on patients’ psychosocial functioning, and assess patients’ and physicians’ perceptions and use of LTx education. Our research will examine patient-physician interactions and explore factors that may determine if/when physicians discuss LTx with CF patients and the impact of ToT on patients’ readiness for LTx discussions. We aim to empower all CF patients to discuss LTx. The proposed R01 will test the impact of ToT on preparedness for LTx discussions and will evaluate patient-physician dynamics that may impact access to LTx in the CF population.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $677,794 )
2026	2026	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Nursing Research	000	4	2/11/2026	NON-COMPETING CONTINUATION	$677,794
														Subtotal = $677,794

Issue Date FY: 2025 ( Subtotal = $692,111 )
2025	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Nursing Research	002	3	6/23/2025	NON-COMPETING CONTINUATION	$69,212
2025	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Nursing Research	003	3	7/16/2025	NON-COMPETING CONTINUATION	$0
2025	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Nursing Research	001	3	2/18/2025	NON-COMPETING CONTINUATION	$0
2025	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Nursing Research	000	3	1/22/2025	NON-COMPETING CONTINUATION	$622,899
														Subtotal = $692,111

Issue Date FY: 2024 ( Subtotal = $707,495 )
2024	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Nursing Research	000	2	1/8/2024	NON-COMPETING CONTINUATION	$635,964
2024	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Nursing Research	002	2	8/9/2024	NON-COMPETING CONTINUATION	-$7,813
2024	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Nursing Research	001	2	5/2/2024	NON-COMPETING CONTINUATION	$79,344
														Subtotal = $707,495

Issue Date FY: 2023 ( Subtotal = $856,255 )
2023	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Nursing Research	000	1	4/19/2023	NEW	$856,255
														Subtotal = $856,255

Grand Total All Awards = $2,933,655

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Preparation for lung transplant discussions and decisions among people with cystic fibrosis

Award Number: R01NR020470

ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/19/2023

PERIOD OF PERFORMANCE END DATE: 01/31/2028

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