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Lifestyle Physical Activity and Cognitive Training Interventions: Preventing Memory Loss in Older Women with Cardiovascular Disease

Award Number: R01NR018443
ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/09/2020
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Lifestyle Physical Activity and Cognitive Training Interventions: Preventing Memory Loss in Older Women with Cardiovascular Disease - Project Summary/Abstract The long-term goal of this program of research is to create and implement multimodal biobehavioral interventions that will prevent or delay memory loss in older adults but will initially focus on women with cardiovascular disease (CVD) due to their disproportionately higher risk. This is important as the prevalence of cognitive dysfunction steeply increases with age after 65 years, affecting women more than men, with greater severity and more rapid decline. A leading risk factor for cognitive dysfunction is CVD, and loss of memory is an early-emerging and particularly distressing type of cognitive dysfunction with serious public health consequences. Evidence shows that both physical activity interventions and cognitive training improve memory in healthy older adults and may synergize when combined in a multimodal intervention as each targets different mechanisms. To date, no study testing physical activity interventions and/or cognitive training has targeted older women with CVD despite their disproportionate risk for memory loss. Moreover, existing physical activity interventions that target memory are largely supervised and structured, which can fail to generate long-term behavior change. In contrast, lifestyle approaches emphasizing small behavioral changes to daily life are more likely to be maintained. Older women and adults with CVD prefer lifestyle interventions in the home and community over structured exercise interventions in a gym or lab. Finally, few combined interventions have included serum biomarkers (e.g., brain-derived neurotrophic factor [BDNF], vascular endothelial growth factor [VEGF], insulin-like growth factor 1 [IGF-1]) that may be early indicators of intervention effects. We will build upon the promising findings of our two lines of research: (1) a lifestyle physical activity intervention targeting older women with CVD, and (2) easily disseminated cognitive training with the BrainHQ program in patients with heart failure. The next step of this research program is to analyze the independent and combined effects of a lifestyle physical activity intervention (Move) and cognitive training (Mind) on memory in women ≥ 65 years with CVD. In the proposed study, we will evaluate the efficacy of the 24-week combined MindMoves on memory performance and memory-related serum biomarkers at 24, 48, and 72 weeks in older women with CVD. Using a 2x2 factorial design, 254 older women with CVD will be recruited from two women’s cardiology clinics and randomized to one of four conditions: (1) Move, (2) Mind, (3) MindMoves, (4) usual care control. Aims are to: (1) determine the independent and combined efficacies of Move and Mind interventions on memory performance, (2) determine the independent and combined efficacies of Move and Mind interventions on memory-related serum biomarkers (BDNF, VEGF, IGF-1), and (3) examine depressive symptoms and genetic factors (APOE-ε4 allele, BDNF genotype) as potential moderators of the association between changes in target behaviors and memory. Findings will provide key knowledge about the ability of practical and scalable multimodal lifestyle interventions to target memory in older women with CVD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$88,986 )
2026	2023	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Nursing Research	000	4	12/11/2025	NON-COMPETING CONTINUATION	-$88,986
														Subtotal = -$88,986

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Nursing Research	000	4	2/13/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $511,364 )
2023	2023	RUSH UNIVERSITY MEDICAL CENTER	1620 W HARRISON ST	CHICAGO	IL	60612	COOK	USA	Nursing Research	000	4	1/25/2023	NON-COMPETING CONTINUATION	$511,364
														Subtotal = $511,364

Issue Date FY: 2022 ( Subtotal = $574,739 )
2022	2022	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Nursing Research	000	3	1/28/2022	NON-COMPETING CONTINUATION	$517,264
2022	2022	RUSH UNIVERSITY MEDICAL CENTER	1620 W HARRISON ST	CHICAGO	IL	60612	COOK	USA	Nursing Research	001	3	4/25/2022	NON-COMPETING CONTINUATION	$57,475
														Subtotal = $574,739

Issue Date FY: 2021 ( Subtotal = $590,105 )
2021	2021	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Nursing Research	000	2	1/22/2021	NON-COMPETING CONTINUATION	$590,105
														Subtotal = $590,105

Issue Date FY: 2020 ( Subtotal = $549,254 )
2020	2020	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Nursing Research	000	1	4/8/2020	NEW	$549,254
														Subtotal = $549,254

Grand Total All Awards = $2,136,476

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Lifestyle Physical Activity and Cognitive Training Interventions: Preventing Memory Loss in Older Women with Cardiovascular Disease

Award Number: R01NR018443

ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/09/2020

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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