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ICLIC-MS for Enhancing Outcomes Research and Clinical Care in Multiple Sclerosis

Award Number: R01NR017431
ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/14/2018
PERIOD OF PERFORMANCE END DATE: 05/31/2024

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ICLIC-MS for Enhancing Outcomes Research and Clinical Care in Multiple Sclerosis - PROJECT SUMMARY Cognitive impairment, physical disability and progressive disease are common but understudied clinical outcomes that substantially impact employment and overall quality of life for individuals with multiple sclerosis (MS). We have recently developed and validated an assisted, web-based tool (ICLIC-MS) for systematic and longitudinal clinical outcomes data collection of MS-validated cognitive function measures, physical disability and progressive disease measures that are not reliably captured in the electronic health record (EHR). In response to FOA# PA-17-010, Use of Technology to Enhance Patient Outcomes and Prevent Illness, our team proposes the study of MS outcomes in a large, multi-ethnic population representative sample of more than 3,000 female and male MS cases from the Kaiser Permanente Northern California Health Plan Membership. We will integrate other EHR data such as important comorbid conditions, use of disease modifying therapy, MRI reports, as well as quality of life measures and employment histories. Our goals include: 1) comprehensively characterizing clinical outcomes in a large MS patient cohort; 2) developing and utilizing an integrated MS health report to enhance patient care; and 3) establishing a resource for clinical outcomes research in MS that also includes whole genomic and environmental exposure data. Findings from our proposed study represent an extraordinary opportunity to facilitate effective long-term management of MS, accelerate progress in the understanding of disease pathogenesis, predict patient trajectories and inform prevention strategies. We have assembled a team with strong expertise in clinical neurology/MS neurology, advanced epidemiologic methods, EHR structure and clinical care within a health maintenance organization, human genomics, biostatistics, and big data approaches.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$72 )
2024	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Nursing Research	000	5	8/28/2024	NON-COMPETING CONTINUATION	-$72
														Subtotal = -$72

Issue Date FY: 2022 ( Subtotal = $576,893 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Nursing Research	000	5	7/1/2022	NON-COMPETING CONTINUATION	$576,893
														Subtotal = $576,893

Issue Date FY: 2021 ( Subtotal = $587,963 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Nursing Research	000	4	6/9/2021	NON-COMPETING CONTINUATION	$587,963
2021	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Nursing Research	001	3	6/24/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $587,963

Issue Date FY: 2020 ( Subtotal = $972,659 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Nursing Research	001	3	7/10/2020	SUPPLEMENT FOR EXPANSION	$397,459
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Nursing Research	000	3	5/7/2020	NON-COMPETING CONTINUATION	$575,200
														Subtotal = $972,659

Issue Date FY: 2019 ( Subtotal = $606,029 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Nursing Research	000	2	6/12/2019	NON-COMPETING CONTINUATION	$606,029
														Subtotal = $606,029

Issue Date FY: 2018 ( Subtotal = $566,927 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Nursing Research	000	1	8/14/2018	NEW	$564,035
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Nursing Research	001	1	9/19/2018	NEW	$2,892
														Subtotal = $566,927

Grand Total All Awards = $3,310,399

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ICLIC-MS for Enhancing Outcomes Research and Clinical Care in Multiple Sclerosis

Award Number: R01NR017431

ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/14/2018

PERIOD OF PERFORMANCE END DATE: 05/31/2024

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