Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Facilitating Functional Independence in Patients Requiring Prolonged Mechanical Ventilation

Award Number: R01NR016055
ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/17/2016
PERIOD OF PERFORMANCE END DATE: 02/28/2022

Group Awards By:

View Award Description

Facilitating Functional Independence in Patients Requiring Prolonged Mechanical Ventilation - DESCRIPTION (provided by applicant): After recovery from critical illness, many patients commonly experience debilitating muscle wasting and weakness, which adversely impacts their functional recovery. These consequences are particularly common in patients who required prolonged mechanical ventilation -- a subgroup of chronically critically ill patients for whom recovery is especially challenging. Current rehabilitation strategies, including standard physical therapy, are insufficient to restore most ventilated patients to their previous level of functional independence. As such, many of these patients require long-term placement in nursing homes. Neuromuscular electrical stimulation (NMES) is an innovative technique that augments muscle size, strength and exercise capacity in deconditioned patients with chronic diseases. NMES is well-tolerated without adverse effects. Because it requires minimal cooperation and does not burden the cardiopulmonary system, NMES may be ideal for reconditioning the muscles and facilitating the return of functional independence in patients requiring prolonged ventilation. Thus, the primary goal of this proposal is to test the effectiveness of NMES (in combination with a standardized physical therapy program) in facilitating independent functional activities in patients requiring prolonged ventilation. To minimize confounders related to acute critical illness patient will be recruited following transfer to a long-term acute care hospital (LTACH) for extended rehabilitation and weaning. Patients will be randomly assigned to receive NMES or sham- NMES of the quadriceps, tibialis anterior, and gastrocnemius muscles of both legs. Both NMES and sham- NMES groups will receive a standardized physical therapy program. Independence in performing functional activities during the LTACH stay (primary outcome) will be quantified using the Functional Status Score for the Intensive Care Unit (FSS-ICU). The long-term impact of NMES on patient-reported outcomes (Barthel index, SF-36, pulmonary functional status scale [PFSS]) and performance-based measurement (Timed-up and go [TUG] test) will also be assessed at three and six months after discharge from the LTACH. Mechanisms of action of NMES in ventilated patients are largely unknown. Accordingly, physiologic response to NMES will be investigated by measuring muscle size (using ultrasonography) and muscle function (using hand-held dynamometry). Information gained from this study about the efficacy of NMES (in combination with a standardized physical therapy program) could provide a paradigm shift in strategies employed at facilitating functional independence in patients requiring prolonged mechanical ventilation. 1


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	CHICAGO ASSOCIATION FOR RESEARCH AND EDUCATION IN SCIENCE	5000 S 5TH AVE & ROOSEVELT RD BLDG 1 RM C303	HINES	IL	60141	COOK	USA	Nursing Research	000	5	8/9/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $370,889 )
2021	2021	CHICAGO ASSOCIATION FOR RESEARCH AND EDUCATION IN SCIENCE	5TH AVE & ROOSEVELT RD BLDG 1 RM C347	HINES	IL	60141	COOK	USA	Nursing Research	000	5	2/23/2021	NON-COMPETING CONTINUATION	$370,889
														Subtotal = $370,889

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	CHICAGO ASSOCIATION FOR RESEARCH AND EDUCATION IN SCIENCE	5TH AVE & ROOSEVELT RD BLDG 1 RM C347	HINES	IL	60141	COOK	USA	Nursing Research	001	4	8/5/2020	NON-COMPETING CONTINUATION	$0
2020	2019	CHICAGO ASSOCIATION FOR RESEARCH AND EDUCATION IN SCIENCE	5TH AVE & ROOSEVELT RD BLDG 1 RM C347	HINES	IL	60141	COOK	USA	Nursing Research	000	4	2/14/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $384,446 )
2019	2019	CHICAGO ASSOCIATION FOR RESEARCH AND EDUCATION IN SCIENCE	5TH AVE & ROOSEVELT RD BLDG 1 RM C347	HINES	IL	60141	COOK	USA	Nursing Research	000	4	2/8/2019	NON-COMPETING CONTINUATION	$384,446
														Subtotal = $384,446

Issue Date FY: 2018 ( Subtotal = $395,205 )
2018	2018	CHICAGO ASSOCIATION FOR RESEARCH AND EDUCATION IN SCIENCE	5TH AVE & ROOSEVELT RD BLDG 1 RM C347	HINES	IL	60141	COOK	USA	Nursing Research	001	3	4/24/2018	NON-COMPETING CONTINUATION	$39,521
2018	2018	CHICAGO ASSOCIATION FOR RESEARCH AND EDUCATION IN SCIENCE	5TH AVE & ROOSEVELT RD BLDG 1 RM C347	HINES	IL	60141	COOK	USA	Nursing Research	000	3	2/28/2018	NON-COMPETING CONTINUATION	$355,684
														Subtotal = $395,205

Issue Date FY: 2017 ( Subtotal = $408,884 )
2017	2017	CHICAGO ASSOCIATION FOR RESEARCH AND EDUCATION IN SCIENCE	5TH AVE & ROOSEVELT RD BLDG 1 RM C347	HINES	IL	60141	COOK	USA	Nursing Research	001	2	7/25/2017	NON-COMPETING CONTINUATION	$40,890
2017	2017	CHICAGO ASSOCIATION FOR RESEARCH AND EDUCATION IN SCIENCE	5TH AVE & ROOSEVELT RD BLDG 1 RM C347	HINES	IL	60141	COOK	USA	Nursing Research	000	2	2/22/2017	NON-COMPETING CONTINUATION	$367,994
														Subtotal = $408,884

Issue Date FY: 2016 ( Subtotal = $421,872 )
2016	2016	CHICAGO ASSOCIATION FOR RESEARCH & ED IN SCIENCE	BLDG ONE RM C307PO BOX 250	HINES	IL	60141	COOK	USA	Nursing Research	000	1	5/17/2016	NEW	$421,872
														Subtotal = $421,872

Grand Total All Awards = $1,981,296

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Facilitating Functional Independence in Patients Requiring Prolonged Mechanical Ventilation

Award Number: R01NR016055

ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/17/2016

PERIOD OF PERFORMANCE END DATE: 02/28/2022

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer