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ALTERNATIVE METHODS FOR CLINICAL RESEARCH

Award Number: R01NR005075
ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2001
PERIOD OF PERFORMANCE END DATE: 03/31/2006

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ALTERNATIVE METHODS FOR CLINICAL RESEARCH - Clinical research is undertaken to evaluate the effectiveness of interventions with known efficacy or of community-based interventions requiring active client participation in their implementation. Conducting this type of clinical research while using the experimental design or randomized clinical trial (RCT) presents methodological and conceptual challenges. These challenges stem from differences between the RCT features and the reality of everyday practice. In practice, clients with different characteristics are cared for, are involved in treatment-related decisions, are not denied treatment if beneficial to them, and participate in the implementation of the intervention under the conditions of everyday life. Incorporating these features into the design of clinical research has been considered as threatening the validity of conclusions regarding the intervention effectiveness. Yet, it is needed to enhance the clinical utility of research findings. The purpose of this methodological study is to determine the influence of selected factors on the validity of a clinical study's conclusions. The specific aims are to determine the influence of clients' characteristics, research design or treatment options, treatment allocation procedures, and intervention components and dosage on clients' decision to enter treatment and outcome achievement. The theory-driven approach to intervention evaluation will guide the study. Different research designs, treatment options, and measurement methods will be used to obtain a comprehensive data set. This data set will permit the conduct of simulation-type analyses to identify the contribution of the methodological and conceptual factors to the validity of conclusions in clinical research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2004 ( Subtotal = $381,553 )
2004	2004	UNIVERSITY OF TORONTO	**	TORONTO, ONTARIO		00000		CAN	Nursing Research	000	4	4/1/2004	NON-COMPETING CONTINUATION	$381,553
														Subtotal = $381,553

Issue Date FY: 2003 ( Subtotal = $356,962 )
2003	2003	UNIVERSITY OF TORONTO	**	TORONTO, ONTARIO		00000		CAN	Nursing Research	000	3		NON-COMPETING CONTINUATION	$356,962
														Subtotal = $356,962

Issue Date FY: 2002 ( Subtotal = $348,731 )
2002	2002	UNIVERSITY OF TORONTO	**	TORONTO, ONTARIO		00000		CAN	Nursing Research	000	2	3/18/2002	NON-COMPETING CONTINUATION	$348,731
														Subtotal = $348,731

Issue Date FY: 2001 ( Subtotal = $327,813 )
2001	2001	UNIVERSITY OF TORONTO	**	TORONTO, ONTARIO		00000		CAN	Nursing Research	000	1	6/11/2001	NEW	$327,813
														Subtotal = $327,813

Grand Total All Awards = $1,415,059

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ALTERNATIVE METHODS FOR CLINICAL RESEARCH

Award Number: R01NR005075

ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2001

PERIOD OF PERFORMANCE END DATE: 03/31/2006

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