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Multimodal MEAs for Parallel Electrical Recording and Sub-second Neuromodulator Sensing

Award Number: R01MH139342
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/13/2024
PERIOD OF PERFORMANCE END DATE: 10/31/2029

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Multimodal MEAs for Parallel Electrical Recording and Sub-second Neuromodulator Sensing - Abstract It has been highly challenging to scale up non-genetic, sub-second neuromodulator sensing or integrate it with electrical recording. Recently, we discovered that mild annealing dramatically improved the electrochemical stability of electroplated carbon coating and transformed conventional microelectrodes into sensors similar to carbon fiber electrodes with excellent neuromodulator-sensing performance based on fast-scan cyclic voltammetry (FSCV). Compared to previous carbonization strategies such as pyrolysis of polymer and laser- induced graphitization, low-temperature, FSCV-stable carbon coating is directly applicable to microelectrode arrays (MEAs), enabling unprecedented spatial scaling of FSCV and unparalleled integration with electrophysiological (ephys) recording, while leveraging decades of MEA research and applications. As a demonstration, we have created a monolithic MEA probe with integrated ephys and FSCV capabilities and validated it in vivo in multiple rodent models. Early studies using this probe in awake rats further revealed an unprecedented correlation between striatal gamma oscillation and dopamine release. In three parallel aims, we intend to optimize, benchmark, and thoroughly validate the platform ephys-FSCV MEA probe for high-density neuromodulator sensing and parallel electrical recording in behaving animals. Our multidisciplinary team consists of a materials scientist and neural engineer (Fang) and a systems neuroscientist (van der Meer), who have jointly produced strong preliminary results with successful in vivo validation and neuroscience studies. In addition to establishing the significant and novel multimodal MEA paradigm, which we envision will enable numerous studies in basic and translational neuroscience, we anticipate that the concept of FSCV-stable carbon-coating and the bioengineering of its up-scaling and ephys-integration are generalizable to many other probes, such as DBS and sEEG electrodes and extensible to further technology evolutions and commercial manufacturing.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $463,040 )
2026	2026	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Mental Health Research Grants	000	2	12/5/2025	NON-COMPETING CONTINUATION	$463,040
														Subtotal = $463,040

Issue Date FY: 2025 ( Subtotal = $517,546 )
2025	2025	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Mental Health Research Grants	000	1	12/13/2024	NEW	$517,546
														Subtotal = $517,546

Grand Total All Awards = $980,586

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Multimodal MEAs for Parallel Electrical Recording and Sub-second Neuromodulator Sensing

Award Number: R01MH139342

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/13/2024

PERIOD OF PERFORMANCE END DATE: 10/31/2029

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