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Sensory contributions to third visual pathway dysfunction in schizophrenia: correlation and causation

Award Number: R01MH138939
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/19/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2030

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Sensory contributions to third visual pathway dysfunction in schizophrenia: correlation and causation - ABSTRACT Schizophrenia (Sz) is associated with deficits in social cognitive function that represent a core feature of the disorder. At present, the neural mechanisms underlying these impairments remain relatively unknown and no specific treatments are available. A recent advance in the conceptualization of human social cognition is the description of a primate specific Third Visual Pathway (TVP) that is specialized for processing of social information. This pathway preferentially utilizes motion input relayed through the primary visual (V1) and motion- sensitive middle temporal cortex (MT+) into the posterior superior temporal cortex (pSTS), an area known to respond to a variety of dynamic social cues including faces and bodies. This project builds from three convergent recent projects within our group. First, we have developed a multimodal ERP/fMRI approach sensitive to TVP dysfunction in Sz and have demonstrated significant interrelated impairments in both MT+ and pSTS activation which, in turn, correlate with impaired face emotion recognition (FER). Second, using naturalistic viewing fMRI (NV-fMRI) we have demonstrated that individuals with Sz show reduced sensitivity to face motion within a social scene and altered patterns of connectivity within TVP structures, including the pulvinar nucleus of the thalamus. Most recently, using co-activation pattern (CAP) state analysis, we have demonstrated decreased occupancy in Sz of states that are associated with increased activity in visual, face processing and TVP regions and increased occupancy of CAP states associated with visual system deactivation. Finally, we have developed expertise in simultaneous application of personalized high-definition transcranial direct current stimulation (pHD-tDCS) concurrent with both fMRI and EEG data acquisition for reversal of visual sensory-level dysfunction in Sz. In preliminary within-subject data, we have observed that pHD-tDCS over MT+ significantly enhances not only MT+ activation to random-dot kinematogram (RDK) stimuli, but also pSTS activation to dynamic face emotion stimuli. These activation changes are associated with correlated improvements in motion sensitivity and FER. Here, we will combine these three currently separate lines of investigation – sensory-level visual assessment, NV-fMRI, and pHD-tDCS - to 1) evaluate mechanisms underlying TVP and social cognitive dysfunction in Sz, and 2) develop potential approaches for future clinical TVP-targeted therapy. Participants will include 120 Sz and 30 healthy control volunteers, who will participate in baseline ERP and fMRI assessments of TVP function along with clinical measures of social function and global outcome. Directional analyses will investigate the relationship between baseline sensory-level visual dysfunction, higher-tier TVP dysfunction, social cognition and global outcome. Sz participants will additionally be randomized to active (cathodal) vs. sham MT+-targeted pHD-tDCS. Convergent ERP and fMRI outcome measures will assess potential causality in the relationships between improved sensory-level motion processing and improved higher-tier TVP function. If successful, the project will provide crucial pilot data for longer term pHD-tDCS-enhanced social cognitive remediation approaches.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $778,548 )
2025	2025	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	140 OLD ORANGEBURG RD BLDG 35	ORANGEBURG	NY	10962	ROCKLAND	USA	Mental Health Research Grants	000	1	9/19/2025	NEW	$778,548
														Subtotal = $778,548

Grand Total All Awards = $778,548

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Sensory contributions to third visual pathway dysfunction in schizophrenia: correlation and causation

Award Number: R01MH138939

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/19/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2030

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