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Dissecting the circuits and population dynamics that represent unconditioned and conditioned stimuli in the ventral hippocampus

Award Number: R01MH136270
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2025
PERIOD OF PERFORMANCE END DATE: 12/31/2029

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Dissecting the circuits and population dynamics that represent unconditioned and conditioned stimuli in the ventral hippocampus - Project Summary Neural population dynamics are in constant flux, with patterns of activity across neurons being updated to account for changes in the relationships between important stimuli in the environment. Recent work from our group has shown that ensembles of CA1 neurons can represent the associations between stimuli and their outcomes, multiplexing stimulus and outcome representations into a format that is stored for days. However, the circuit mechanisms by which the ventral hippocampus performs these computations remains unknown. In this proposal we will leverage anatomical targeting of discrete cell classes, large-scale population recording, computational tools, and cell-type specific manipulation to understand how classes of ventral CA1 neuron acquire, update and store information during associative learning. In Aim 1 we will understand how vCA1 neurons that project to the nucleus accumbens, amygdala and/or mPFC acquire responses to conditioned and unconditioned cues through learning. In Aim 2 we will determine how these classes of neurons flexibly change their responses with switches in stimulus or outcome valences. In Aim 3 we will ask if information related to conditioned and unconditioned stimuli converge in vCA1 and how this process facilitates acquisition and storage of associative memories. Understanding these basic principles of vCA1 encoding properties will be crucial to efforts to understand the circuit mechanisms that contribute cognitive and emotional disorders with underlying dysfunction in associative learning processes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $781,119 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Mental Health Research Grants	000	1	2/25/2025	NEW	$781,119
														Subtotal = $781,119

Grand Total All Awards = $781,119

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Dissecting the circuits and population dynamics that represent unconditioned and conditioned stimuli in the ventral hippocampus

Award Number: R01MH136270

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2025

PERIOD OF PERFORMANCE END DATE: 12/31/2029

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