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Building a Granular Brain-Wide Map of the Serotonin System

Award Number: R01MH136237
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/21/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2029

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Building a Granular Brain-Wide Map of the Serotonin System - Project Summary As a brain-wide neuromodulator, serotonin regulates a vast array of cognitive and emotional functions. It can potently induce plasticity in the adult brain. And with this power, it can promote learning and open windows for change and healing in neuropsychiatric conditions. It also has important roles in adaptive behavioral responses to stress, affiliative social behavior, aggression, and sleep. It is no wonder that serotonergic agents are widely used in psychiatry across several diagnoses. However, current treatments have many limitations. Most affect the serotonin system globally without regard to its underlying heterogeneity. To modulate the system in a targeted way, we need to understand how it is wired, and what each wire does. Serotonergic neurons in the dorsal and medial raphe nuclei send axonal projections throughout the entire brain. In this project, we will map these projections, with single cell resolution barcoding approach, to all their major brain targets. We will determine the strength of the projection to each target, and we will determine which target areas are coregulated by collateral projections, forming subnetworks. Furthermore, we will determine the molecular and functional identity of the neurons in each projection. Identifying the anatomical, molecular, and functional brain-wide serotonergic subnetworks could lead to new approaches for targeted therapies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $797,281 )
2026	2026	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	3	1/27/2026	NON-COMPETING CONTINUATION	$797,281
														Subtotal = $797,281

Issue Date FY: 2025 ( Subtotal = $807,740 )
2025	2025	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	2	9/23/2025	NON-COMPETING CONTINUATION	$121,161
2025	2025	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	2	2/18/2025	NON-COMPETING CONTINUATION	$686,579
														Subtotal = $807,740

Issue Date FY: 2024 ( Subtotal = $822,456 )
2024	2024	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	1	5/21/2024	NEW	$822,456
														Subtotal = $822,456

Grand Total All Awards = $2,427,477

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Building a Granular Brain-Wide Map of the Serotonin System

Award Number: R01MH136237

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/21/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2029

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