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Structure-function cell atlas for norepinephrine and serotonin neurons

Award Number: R01MH134833
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/22/2024
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Structure-function cell atlas for norepinephrine and serotonin neurons - Project Abstract Norepinephrine (NE) and serotonin (5-HT) are neurotransmitters released by a small number of neurons in the locus coeruleus (LC) and dorsal raphe (DR), respectively. Each group of neurons provides extensive innervation of most of the brain. Although these groups of cells are often considered to be homogenous, recent data indicates the existence of subclasses of each neuron. This proposal aims to generate multi-scale data on each system, comprising molecular, genetic, anatomical, physiological, and behavioral experiments. Our team is in a unique position to integrate across experiments and develop a new understanding of the subclasses of LC-NE and DR-5-HT neurons and their functions during behavior. Three aims test specific questions about the cell types and functions of LC-NE and DR-5-HT neurons in mice: 1) LC-NE neuron subclasses have distinct biophysical properties and axonal projections; 2) subclasses of DR-5-HT neurons have distinct biophysical properties and axonal projections; and 3) subclasses of LC-NE and DR-5-HT neurons have different functions during dynamic decision making. Our experiments will be used to develop a comprehensive classification of NE and 5-HT neuronal subclasses and will be used to generate reagents to target those cells.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,442,157 )
2025	2025	ALLEN INSTITUTE	615 WESTLAKE AVE N	SEATTLE	WA	98109	KING	USA	Mental Health Research Grants	000	2	12/20/2024	NON-COMPETING CONTINUATION	$1,442,157
														Subtotal = $1,442,157

Issue Date FY: 2024 ( Subtotal = $1,592,895 )
2024	2024	ALLEN INSTITUTE	615 WESTLAKE AVE N	SEATTLE	WA	98109	KING	USA	Mental Health Research Grants	000	1	3/22/2024	NEW	$1,592,895
														Subtotal = $1,592,895

Grand Total All Awards = $3,035,052

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Structure-function cell atlas for norepinephrine and serotonin neurons

Award Number: R01MH134833

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/22/2024

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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