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Multimodal brain imaging of the neural effects of methylphenidate in patients with ADHD

Award Number: R01MH133453
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2023
PERIOD OF PERFORMANCE END DATE: 11/30/2028

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Multimodal brain imaging of the neural effects of methylphenidate in patients with ADHD - There is continued interest to develop novel pharmacological treatments for attention deficit hyperactivity disorder (ADHD), in part because of its high prevalence in the community, and lack of optimal response to current medications, including intolerable side effects. Central nervous system (CNS) pharmacodynamic (PD) measures have not been well characterized in pediatric and adolescent populations, which is important for future drug development. Brain imaging tools are ideal CNS PD measures in children because they are non-invasive and reproducible. Our goal is to understand the neural correlates of treating ADHD with methylphenidate, specifically in children and adolescents. First, we propose to determine the dose-dependent changes in cognitive task-related neural activity after acute methylphenidate using functional magnetic resonance imaging (fMRI, Aim 1). Then we will identify the changes in brain glutamate and other brain metabolites after acute methylphenidate using high-field strength magnetic resonance spectroscopy (MRS), and determine if these changes in brain chemistry correlate with changes in brain function (Aim 2). Data from this study will shed light onto the pathophysiology of the cognitive symptoms of ADHD and the neural response to treatment with stimulants, which will guide future development of novel treatments and could serve as CNS PD measures in future treatment trials. Furthermore, we will determine the utility of these CNS PD measures in children and adolescents that will lay the groundwork for developing pediatric brain imaging measures for other drugs and other CNS disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $679,840 )
2026	2026	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Mental Health Research Grants	000	3	12/10/2025	NON-COMPETING CONTINUATION	$679,840
														Subtotal = $679,840

Issue Date FY: 2025 ( Subtotal = $681,863 )
2025	2025	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Mental Health Research Grants	001	2	9/22/2025	NON-COMPETING CONTINUATION	$102,280
2025	2025	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Mental Health Research Grants	000	2	12/12/2024	NON-COMPETING CONTINUATION	$579,583
														Subtotal = $681,863

Issue Date FY: 2024 ( Subtotal = $700,166 )
2024	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Mental Health Research Grants	001	1	5/3/2024	NEW	$68,716
2024	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Mental Health Research Grants	000	1	11/16/2023	NEW	$631,450
														Subtotal = $700,166

Grand Total All Awards = $2,061,869

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Multimodal brain imaging of the neural effects of methylphenidate in patients with ADHD

Award Number: R01MH133453

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2023

PERIOD OF PERFORMANCE END DATE: 11/30/2028

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