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Emotional Arousal and its Neurobehavioral Associations during Development

Award Number: R01MH130901
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/13/2024
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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Emotional Arousal and its Neurobehavioral Associations during Development - Project Summary Emotional arousal is a key bio-behavioral target for investigations of transdiagnostic mechanisms underlying the development of pathological emotional states (e.g., anxiety, depression, irritability). While arousal is different from valence (positive or negative affect), arousal creates a readiness for valenced states, and its temporal and magnitude properties dictate the nature of experienced emotions. Arousal is one of the first affective states to emerge developmentally, and it is highly susceptible to stress exposures; therefore, delineating trajectories of psychopathology associated with arousal requires a developmental approach. As central as phasic changes in arousal are to healthy emotional functioning, reliably and objectively studying emotional arousal across the first two decades of life is challenging because existing probes may not be appropriate for use across a wide range of ages. The current proposal develops a straight-forward, controlled, and standardized tool – a looming auditory stimulus – to measure phasic changes in arousal to provide a common metric that can be used across development and diverse designs and settings. The work in the proposal will measure the looming task’s psychometric properties during pupillometry, autonomic responses (HR, SCR), and behavioral ratings. Then we will assess how these measures track affect-related psychopathology (anxiety, depression, irritability) during development. Finally, we will identify associations between arousal-induced brain function and affect-related psychopathological symptoms during development. Aim I establishes validity and reliability of a simple arousal task from the preschool period through young adulthood (2-25 years). Aim II assesses how arousal tracks individual differences in psychopathology symptoms (anxiety, depression, irritability) in a high-risk developmental sample. Aim III identifies the associations between arousal-related brain function and psychopathological symptoms (anxiety, depression, irritability) during development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $667,712 )
2026	2026	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	000	3	6/10/2026	NON-COMPETING CONTINUATION	$667,712
														Subtotal = $667,712

Issue Date FY: 2025 ( Subtotal = $643,385 )
2025	2025	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	001	2	8/14/2025	NON-COMPETING CONTINUATION	$643,385
2025	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	000	1	2/14/2025	NEW	$0
														Subtotal = $643,385

Issue Date FY: 2024 ( Subtotal = $685,060 )
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	000	1	8/13/2024	NEW	$685,060
														Subtotal = $685,060

Grand Total All Awards = $1,996,157

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Emotional Arousal and its Neurobehavioral Associations during Development

Award Number: R01MH130901

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/13/2024

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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