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Resilient Emotion Regulation Development in a South African Birth Cohort

Award Number: R01MH130578
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/02/2023
PERIOD OF PERFORMANCE END DATE: 01/31/2026
AWARD TERMINATION DATE: 08/26/2026

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Resilient Emotion Regulation Development in a South African Birth Cohort - Project Summary Adolescents in low-/middle-income countries (LMICs) lose substantial developmental potential from exposure to early adversities, with an estimated 250 million children at risk of not reaching their developmental potential. Such catastrophic loss of human potential occurs in the context of the 10/90 divide – 10% of our current scientific knowledge is produced in or by LMICs that comprise 90% of the world’s population. This skewed evidence base has led to a limited understanding of patterns of risk and resilience in brain development for the vast majority of the world’s adolescents. Emotion regulation (ER), the internal and external process that modifies the experience or expression of an emotion, is a key mediator between early adversity and outcomes, and yet, the lack of data on ER in youth from most of the world is of concern given evidence that context shapes the socialization of emotion. The proposed research addresses this significant mental health problem by combining a) sophisticated data analytic techniques and b) community-guided/-participatory research applied to longitudinal multimodal brain imaging, high-dimensional behavioral assessments, and comprehensive defining of environmental exposures (both adverse and protective) from a well-established and deeply-characterized birth cohort of early adolescents in Cape Town, South Africa. The goal of the present work is to create an explanatory model for the impact of protective factors on neurodevelopmental trajectories underlying ER resilience. The premise is that early adversities are heterogeneous, powerful events that significantly increase the risk of poor ER, but also that resilience factors experienced during early adolescence can mitigate/ameliorate these risks. Therefore, prediction of ER outcomes requires cutting-edge, sophisticated data analytic methods. We hypothesize that data- driven approaches will 1) more precisely define ER behavioral profiles for adolescents living in LMICs who are exposed to heterogeneous adversities, and 2) provide a robust explanatory model for links between resilience factors and ER neurobehavioral trajectories. Aim 1 subtypes 525 12-13 year-old adolescents in an established LMIC birth cohort based on early environmental exposures and then tests for neural correlates of ER behavioral resilience (based on MRI measures of functional connectivity, task-based activity, and morphometry) accounting for early adversity subtype. Aim 2 identifies changes in neurobiology that underlie improvements in adolescent ER and develops an explanatory model to predict 2-year (Time2-Time1) longitudinal ER resilience trajectory subtypes based on concurrent environmental exposures (protective and adverse), accounting for early adversity subtype. The inclusion of participant-sex and pubertal status will identify potential divergence in pathways across early adolescence. We use a prospective approach together with machine learning methods with the goal of improving precision and inclusivity in recognizing and characterizing resilience to socio-economic, structural, health, and interpersonal adversities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $436,897 )
2026	2025	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	000	3	8/26/2026	TERMINATION	$436,897
2026	2025	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	001	3	8/27/2026	TERMINATION	$0
														Subtotal = $436,897

Issue Date FY: 2025 ( Subtotal = $995,148 )
2025	2025	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	000	3	9/2/2025	NON-COMPETING CONTINUATION	$558,251
2025	2025	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	001	3	9/4/2025	SUPPLEMENT FOR EXPANSION	$436,897
														Subtotal = $995,148

Issue Date FY: 2024 ( Subtotal = $992,759 )
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	000	2	7/15/2024	NON-COMPETING CONTINUATION	$992,759
														Subtotal = $992,759

Issue Date FY: 2023 ( Subtotal = $1,065,119 )
2023	2023	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	202 LOW LIBRARY 535 W 116 ST MC 4309,	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	000	1	8/2/2023	NEW	$1,065,119
2023	2023	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	202 LOW LIBRARY 535 W 116 ST MC 4309,	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	001	1	8/29/2023	NEW	$0
														Subtotal = $1,065,119

Grand Total All Awards = $3,489,923

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Resilient Emotion Regulation Development in a South African Birth Cohort

Award Number: R01MH130578

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/02/2023

PERIOD OF PERFORMANCE END DATE: 01/31/2026

AWARD TERMINATION DATE: 08/26/2026

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