Wednesday, March 18, 2026 3/18/2026

Parent-child proximity and emerging psychopathology

Award Number: R01MH129634
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/05/2022
PERIOD OF PERFORMANCE END DATE: 02/28/2027
AWARD TERMINATION DATE: 04/28/2025

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Parent-child proximity and emerging psychopathology - PROJECT SUMMARY/ABSTRACT The caregiving environment children experience is the most important modifiable feature for shaping brain development and influencing subsequent mental health. Building from knowledge of infant mental health and developmental neuroscience, this NIMH BRAINS award application is designed to advance our understanding of how children’s experiences with their caregivers during infancy, a developmental period characterized by heightened brain plasticity, influences brain and behavioral development. Specifically, we will use innovative methods to characterize multiple aspects of the early caregiving environment in relation to changes in brain structural and functional connectivity that are believed to contribute to the onset of mental disorders. The application of new tools, coupled with traditional metrics, will improve our measurement of children’s experiences using a child-centered approach (i.e., capturing children’s contact with multiple caregivers). To do this, we will recruit 150 women in pregnancy and, following birth, conduct assessments in children’s daily ecological context at ages 1, 6, 12, and 18 months. This project introduces a wearable device technology that can dynamically, unobtrusively, and continuously measure patterns of physical proximity between children and caregivers, regardless of physical location. In addition to children’s proximity to caregivers, we will obtain ecological assessments of language exposure and observation-based caregiver sensitivity and examine the convergence and divergence among these different ways of capturing children’s experiences (Specific Aim 1). While prior research suggests that greater environmental enrichment leads to lower symptoms of psychopathology, the lack of granularity in measurement (i.e., not capturing the full continuum of relative psychosocial neglect–enrichment) has precluded the ability to characterize the shape of these associations (e.g., linear, nonlinear). We will study children selected to range in experiences along the neglect–enrichment continuum and use repeated neuroimaging of infant brain structural and functional connectivity and repeated behavioral assessments to explore the possible profile of the associations between aspects of the caregiving environment and changes in brain and behavior (Specific Aim 2). Last, we will examine how changes in emotion regulation and emotion reasoning circuitry are associated with signs of emerging psychopathology at age 18 months in order to test whether, when, and how variations in early experience influence risk for psychopathology through changes in emotion-related circuitry (Specific Aim 3). Here, neuroimaging is particularly advantageous as it allows us to examine the maturation of emotion-related networks from birth and, importantly, prior to the onset of detectable mental health difficulties. Achievement of the aims of this proposal is expected to meet NIMH’s objectives to determine the biological and psychological mechanisms by which experience affects neural and behavioral development, with direct applications for prevention and early intervention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $720,774 )
2026	2026	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Mental Health Research Grants	000	5	3/2/2026	NON-COMPETING CONTINUATION	$720,774
														Subtotal = $720,774

Issue Date FY: 2025 ( Subtotal = $744,672 )
2025	2025	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Mental Health Research Grants	004	4	9/23/2025	NON-COMPETING CONTINUATION	$111,699
2025	2025	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Mental Health Research Grants	002	4	4/25/2025	NON-COMPETING CONTINUATION	$0
2025	2025	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Mental Health Research Grants	000	4	4/7/2025	NON-COMPETING CONTINUATION	$670,206
2025	2025	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Mental Health Research Grants	001	4	4/9/2025	NON-COMPETING CONTINUATION	-$37,233
2025	2024	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Mental Health Research Grants	003	3	4/28/2025	TERMINATION	$0
														Subtotal = $744,672

Issue Date FY: 2024 ( Subtotal = $847,637 )
2024	2024	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Mental Health Research Grants	001	3	4/5/2024	SUPPLEMENT FOR EXPANSION	$91,905
2024	2024	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Mental Health Research Grants	000	3	2/22/2024	NON-COMPETING CONTINUATION	$680,159
2024	2024	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Mental Health Research Grants	002	3	8/14/2024	NON-COMPETING CONTINUATION	$75,573
														Subtotal = $847,637

Issue Date FY: 2023 ( Subtotal = $832,080 )
2023	2023	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Mental Health Research Grants	000	2	3/15/2023	NON-COMPETING CONTINUATION	$752,830
2023	2023	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Mental Health Research Grants	001	2	4/3/2023	SUPPLEMENT FOR EXPANSION	$79,250
														Subtotal = $832,080

Issue Date FY: 2022 ( Subtotal = $804,165 )
2022	2022	VANDERBILT UNIVERSITY, THE	110 21ST AVENUE S STE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Mental Health Research Grants	000	1	5/3/2022	NEW	$804,165
														Subtotal = $804,165

Grand Total All Awards = $3,949,328

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Parent-child proximity and emerging psychopathology

Award Number: R01MH129634

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/05/2022

PERIOD OF PERFORMANCE END DATE: 02/28/2027

AWARD TERMINATION DATE: 04/28/2025

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