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Optimizing digital health technologies to improve therapeutic skill use and acquisition

Award Number: R01MH129478
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2022
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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Optimizing digital health technologies to improve therapeutic skill use and acquisition - Project Summary Binge eating (i.e., eating a large amount of food within a discrete time period accompanied by a sense of loss of control over eating) is a key symptom of several eating disorders including bulimia nervosa (BN) and binge eating disorder (BED). While cognitive behavioral therapy (CBT) can be an effective treatment approach for binge eating, 40-50% of patients with BED and nearly 70% of patients with BN fail to achieve remission. A growing body of research suggests that a key reason many patients may fail to benefit from CBT is suboptimal rates of skill acquisition (i.e., the ability to successfully perform a skill learned in treatment) and utilization (i.e., the frequency with which a patient practices or employs therapeutic skills). Poor skill use and acquisition may be particularly high among certain subsets of patients such as those who experience deficits in self-regulation. This research suggests that treatment augmentations that could improve skill use and acquisition (particularly for those who need additional support to succeed in CBT) could have high potential to enhance outcomes. The NIMH has recently identified that digital health technologies (DHTs) have high potential to “promote between-session skill practice/acquisition” and have selected this as a high priority research initiative (NOT- MH-18-031). DHTs may be able to improve skill use and acquisition via several pathways, one of which is the use of micro-interventions (i.e., short digital interventions delivered to people as they go about their daily lives). Micro-interventions can range in complexity from something as simple as an automated reminder to practice a therapeutic skill to advanced just-in-time adaptive intervention (JITAI) systems that use machine learning or other advanced algorithms to deliver personally tailored interventions in specific moments of need. Recent pilot work from our team supports the utility of JITAIs as a way to improve skill utilization and acquisition when used as a treatment augmentation but did not compare JITAIs to more simple automated reminder micro- interventions. Additionally, our pilot work also found that frequent monitoring of skill use was in and of itself a surprisingly effective method for encouraging skill practice. These results suggest that the added complexity of JITAIs may not be necessary for all individuals to experience benefit from a DHT augmentation. The ability to develop maximally effective DHTs requires the use of a larger clinical trial that can help to identify which digital components (and at which complexity) are most effective at improving skill use and acquisition as well clinical outcomes. We propose to use a 2 x 3 full factorial design in which 264 individuals with BN or BED are assigned to one of six treatment conditions, i.e., representing each permutation of self-monitoring complexity (Skills-Monitoring On vs. Skills-Monitoring Off) and micro-intervention complexity (No Micro- Interventions vs. Automated Reminder Messages vs. JITAIs) as an augmentation to CBT. Results of the component analysis set up future work to evaluate an optimized DHT containing only effective components (which can be expected to have superior target engagement, efficacy, efficiency and disseminability).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $515,741 )
2026	2026	THE NEMOURS FOUNDATION	1600 ROCKLAND RD	WILMINGTON	DE	19803	NEW CASTLE	USA	Mental Health Research Grants	001	4	8/17/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$515,741
2026	2024	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	3	8/6/2026	NON-COMPETING CONTINUATION	$0
2026	2024	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	002	3	8/28/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $515,741

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	002	3	9/16/2025	NON-COMPETING CONTINUATION	$0
2025	2024	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	001	3	3/13/2025	NON-COMPETING CONTINUATION	$0
2025	2024	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	3	1/20/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $578,138 )
2024	2024	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	001	3	7/22/2024	NON-COMPETING CONTINUATION	$57,813
2024	2024	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	3	2/8/2024	NON-COMPETING CONTINUATION	$520,325
														Subtotal = $578,138

Issue Date FY: 2023 ( Subtotal = $578,138 )
2023	2023	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	2	3/6/2023	NON-COMPETING CONTINUATION	$578,138
														Subtotal = $578,138

Issue Date FY: 2022 ( Subtotal = $664,104 )
2022	2022	DREXEL UNIVERSITY	3141 CHESTNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	1	3/25/2022	NEW	$664,104
														Subtotal = $664,104

Grand Total All Awards = $2,336,121

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Optimizing digital health technologies to improve therapeutic skill use and acquisition

Award Number: R01MH129478

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2022

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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