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A multi-level approach to improve HIV prevention and care for transgender women of color

Award Number: R01MH129285
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2023
PERIOD OF PERFORMANCE END DATE: 06/30/2030

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A multi-level approach to improve HIV prevention and care for transgender women of color - ABSTRACT In the United States, persistent gaps in HIV prevention and care continua contribute to limited uptake of pre-exposure prophylaxis (PrEP) among individuals at risk for HIV and reduced viral suppression rates among those living with HIV. To address these challenges, this study will evaluate the effectiveness of Let’s Be, a status-neutral, peer-supported intervention designed to improve engagement across the HIV prevention and care continuum. Let’s Be integrates two evidence-based components that can be offered via telehealth: (1) a group-level behavioral intervention and (2) individual-level peer navigation. Both components have previously demonstrated feasibility and acceptability in studies involving populations with elevated HIV risk. This Hybrid Type 1 effectiveness-implementation study will assess the intervention’s impact on PrEP adherence and viral suppression as co-primary outcomes. A secondary outcome will evaluate a composite indicator of HIV risk reduction behaviors. We will enroll and randomize 250 participants in New York City, NY, and Detroit, MI, stratified by HIV status and study site. Participants will be followed over 12 months, with data collection via dried blood spots and structured behavioral assessments. Key advisors will contribute ongoing input to guide delivery and identify practical considerations for future scale-up. This study will generate evidence on the effectiveness of a flexible, telehealth-capable integrated intervention model while informing strategies for broader dissemination. If successful, Let’s Be has the potential to enhance HIV prevention and treatment outcomes across priority jurisdictions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,122,604 )
2026	2026	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	002	3	9/7/2026	NON-COMPETING CONTINUATION	$1,122,604
2026	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	2	8/25/2026	OTHER REVISION	$0
2026	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	2	8/27/2026	OTHER REVISION	$0
														Subtotal = $1,122,604

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	002	2	7/22/2025	OTHER REVISION	$0
2025	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	2	3/24/2025	TERMINATION	$0
2025	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	2	7/10/2025	OTHER REVISION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	2	8/19/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $96,895 )
2023	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	2	3/11/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,132,842
2023	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Mental Health Research Grants	000	1	3/10/2023	NEW	-$1,035,947
2023	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	002	2	8/16/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $96,895

Issue Date FY: 2022 ( Subtotal = $1,035,948 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Mental Health Research Grants	000	1	8/31/2022	NEW	$1,035,948
														Subtotal = $1,035,948

Grand Total All Awards = $2,255,447

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A multi-level approach to improve HIV prevention and care for transgender women of color

Award Number: R01MH129285

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2023

PERIOD OF PERFORMANCE END DATE: 06/30/2030

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