Tuesday, September 16, 2025 9/16/2025

Risk and Resilience in Urban Black American Acute Trauma Survivors

Award Number: R01MH128982
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/16/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Risk and Resilience in Urban Black American Acute Trauma Survivors - PROJECT ABSTRACT Trauma is common and increases risk for a host of negative health outcomes, most notably posttraumatic stress disorder (PTSD). Given the potential harmful sequelae of trauma exposure, it is crucial to identify acute post-trauma risk factors that predict chronic PTSD. Moreover, urban racial/ethnic minorities can experience significant environmental stress that puts them at particularly high risk for PTSD. At this juncture relatively little data exists to aid in prediction of risk specific to urban racial minorities, or that takes into account how disadvantage and minority stress may impact neurobiological stress systems in the months following trauma, and how that affects risk for long-term distress. Thus, under the guidance of a community advisory board our team will 1) identify acute post-trauma neurobehavioral predictors of risk for chronic PTSD among urban Black Americans, with a focus on prefrontal-subcortical function during processing of threat, 2) characterize how the longitudinal interaction of socioenvironmental risk and resilience factors and biological stress markers following trauma impacts risk, and 3) use machine learning to identify the most robust set of predictors of chronic PTSD drawn from a comprehensive assessment of neuroimaging, biomarkers, self-report and geocoded risk and resilience variables. We will recruit 190 adults who identify as Black or African American from the Emergency Department at Froedtert Hospital/Medical College of Wisconsin in Milwaukee, and conduct comprehensive assessments at 2 weeks, and 3, 6, and 12 months following trauma exposure. The two-week and 12-month assessments will include measures of neural systems for threat processing, including both anticipation of and reactivity to threat. All visits will include measures of PTSD and other symptoms, neurobiological stress markers, particularly endocannabinoids, and socioenvironmental risk and resilience factors, especially those relevant for urban Black Americans. We will examine how acute post-trauma neurocircuitry variables (2 week) predict PTSD and other outcomes twelve months later, and how pre-trauma environmental variables (resource deprivation, child maltreatment, violence exposure) moderate this relationship (Aim 1). We will also assess how, in the months following trauma, socio-environmental risk and resilience factors influence neurobiological stress systems, and how this interaction impacts risk for PTSD, poor physical health, and emotion regulation neurocircuitry at twelve months (Aim 2). We will use both hypothesis-driven analyses focusing on a priori specified predictors (Aims 1 and 2), as well as comprehensive data-driven machine learning analyses (Aim 3). This approach will allow for determination of the additional utility of neurobiological markers for predicting risk beyond previously identified self-report indicators. We expect this project to lead to identification of predictors of PTSD following trauma for urban Black Americans at high risk that are linked to underlying processes (hyper-responsivity to threat, aberrant neurobiological stress response) that can inform preventive interventions, ultimately improving the quality of life for urban Black American trauma survivors.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $694,400 )
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	3203 N DOWNER AVE # 273	MILWAUKEE	WI	53211	MILWAUKEE	USA	Mental Health Research Grants	000	5	8/27/2025	NON-COMPETING CONTINUATION	$694,400
														Subtotal = $694,400

Issue Date FY: 2024 ( Subtotal = $713,411 )
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	3203 N DOWNER AVE # 273	MILWAUKEE	WI	53211	MILWAUKEE	USA	Mental Health Research Grants	000	4	7/30/2024	NON-COMPETING CONTINUATION	$713,411
														Subtotal = $713,411

Issue Date FY: 2023 ( Subtotal = $657,770 )
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	3203 N DOWNER AVE	MILWAUKEE	WI	53211	MILWAUKEE	USA	Mental Health Research Grants	002	3	7/29/2023	NON-COMPETING CONTINUATION	$657,770
2023	2022	UNIVERSITY OF WISCONSIN SYSTEM	3203 N DOWNER AVE STE 273	MILWAUKEE	WI	53211	MILWAUKEE	USA	Mental Health Research Grants	001	2	10/18/2022	NON-COMPETING CONTINUATION	$0
2023	2021	UNIVERSITY OF WISCONSIN SYSTEM	3203 N DOWNER AVE STE 273	MILWAUKEE	WI	53211	MILWAUKEE	USA	Mental Health Research Grants	000	1	10/18/2022	NEW	$0
														Subtotal = $657,770

Issue Date FY: 2022 ( Subtotal = $722,101 )
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	3203 N DOWNER AVE STE 273	MILWAUKEE	WI	53211	MILWAUKEE	USA	Mental Health Research Grants	000	2	8/19/2022	NON-COMPETING CONTINUATION	$722,101
														Subtotal = $722,101

Issue Date FY: 2021 ( Subtotal = $791,975 )
2021	2021	UNIVERSITY OF WISCONSIN SYSTEM	3203 N DOWNER AVE STE 273	MILWAUKEE	WI	53211	MILWAUKEE	USA	Mental Health Research Grants	000	1	9/16/2021	NEW	$791,975
														Subtotal = $791,975

Grand Total All Awards = $3,579,657

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Risk and Resilience in Urban Black American Acute Trauma Survivors

Award Number: R01MH128982

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/16/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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