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A Wireless, Multimodal Neural Probe for Simultaneous Membrane-Free Neurochemical Sampling and Neuropharmacology

Award Number: R01MH128721
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/15/2022
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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A Wireless, Multimodal Neural Probe for Simultaneous Membrane-Free Neurochemical Sampling and Neuropharmacology - PROJECT SUMMARY/ABSTRACT Mental disorders, such as depression, anxiety, and many others, affect the quality of life of millions of people worldwide. High-molecular-weight neurochemicals, such as neuropeptides and other polypeptide neurochemicals, play critical roles in various aspects of these mental disorders. However, despite intensive work, current measurement technologies, such as microdialysis or cyclic voltammetry, lack the spatial and temporal precision and the molecular specificity to detect these larger molecules. Our long-term goal is to develop advanced tools and approaches to understand where, when, and how neuropeptide corelease modulates diverse behavioral outputs of the brain. Our immediate goal is to develop, optimize, benchmark, and fully validate a wireless, multimodal neural probe for simultaneous membrane-free neurochemical sampling and neuropharmacology in freely moving mice and rats. We will achieve this goal by pursuing the following three specific aims: (1) to develop and characterize a push-pull microsystem for membrane-free neurochemical sampling; (2) to develop a wireless, multimodal neural probe for simultaneous membrane-free neurochemical sampling and neuropharmacology; and (3) to evaluate and characterize the efficiency and functionality of the wireless, multimodal neural probe in vivo in freely moving mice and rats. The proposed research is innovative for four key reasons: First, the wireless neural probe combines the membrane-free, push-pull microsystem with a time-sequential fluid sampling device, thereby enabling the sampling of multiple neuropeptides and proteins with spatiotemporal precision. Second, the probe provides simultaneous neuropharmacology and membrane- free neurochemical sampling in awake, freely moving mice and rats, thereby making it possible to sample multiple high-molecular-weight neurochemicals and in turn guide localized pharmacological stimulation through a single platform. Third, the fully wireless, battery-free operation prevents the limitations that conventional wires and tubing connected to external hardware impose on the natural behavior of animals, thereby offering a tremendous opportunity to link neuromodulation and/or neurochemical release with natural animal behaviors related to mental disorders. Finally, the probe has lightweight construction, thereby enabling the application in small animals, such as mice, without inducing physical stress or disrupting their natural behaviors, a condition important for behavior studies related to mental disorders. The successful completion of the proposed research will yield wireless, multimodal neural probes with several innovative features for simultaneous membrane- free neurochemical sampling and neuropharmacology during freely moving behaviors. We believe that these neural probe systems will be of great interest to the neuroscience community as a way of elucidating the molecular mechanisms underlying aberrant behavior, circuit dysfunction and altered neurochemistry associated with mental disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $561,968 )
2026	2026	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Mental Health Research Grants	000	5	5/14/2026	NON-COMPETING CONTINUATION	$561,968
														Subtotal = $561,968

Issue Date FY: 2025 ( Subtotal = $568,824 )
2025	2025	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Mental Health Research Grants	000	4	4/17/2025	NON-COMPETING CONTINUATION	$483,501
2025	2025	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Mental Health Research Grants	001	4	6/11/2025	NON-COMPETING CONTINUATION	$85,323
														Subtotal = $568,824

Issue Date FY: 2024 ( Subtotal = $583,698 )
2024	2024	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Mental Health Research Grants	000	3	5/1/2024	NON-COMPETING CONTINUATION	$583,698
														Subtotal = $583,698

Issue Date FY: 2023 ( Subtotal = $491,728 )
2023	2023	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Mental Health Research Grants	000	2	4/18/2023	NON-COMPETING CONTINUATION	$491,728
														Subtotal = $491,728

Issue Date FY: 2022 ( Subtotal = $491,728 )
2022	2022	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Mental Health Research Grants	000	1	6/15/2022	NEW	$491,728
2022	2022	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Mental Health Research Grants	001	1	7/20/2022	NEW	$0
														Subtotal = $491,728

Grand Total All Awards = $2,697,946

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A Wireless, Multimodal Neural Probe for Simultaneous Membrane-Free Neurochemical Sampling and Neuropharmacology

Award Number: R01MH128721

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/15/2022

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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