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What works for Whom in Pediatric OCD

Award Number: R01MH128595
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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What works for Whom in Pediatric OCD - Project Summary/Abstract Improving patient outcomes will be enhanced by understanding “what works, for whom?” enabling better matching of patients to available treatments. Despite a wealth of research seeking to optimize CBT outcomes for pediatric obsessive-compulsive disorder (OCD), we have limited understanding about how to match patients with the appropriate treatment package. Past research has identified patient characteristics that may influence treatment response, including age, symptom severity, comorbidities, and previous treatment history. Unfortunately, findings have been inconsistent due to limited sample size, a focus on one modifier at a time, and difficulty integrating results across trials with different sample characteristics. Between-trial differences in sample characteristics severely limit conventional meta-analytic tools, greatly complicating cross-trial comparisons of treatment efficacy. This project will use individual-participant-data from 27 trials and data from two clinical populations and utilize recent advancements in transportability methods facilitates understanding “what works, for whom?” Transportability methods include causal analytic approaches to extend inferences from trial samples to target populations when there are marked differences in the distribution of sample characteristics between trials and the target population. Robust statistical models are used to address between-trial differences in covariates, enabling the transportation of causal estimates from trial samples to target populations. Under explicit causal and statistical assumptions, the transported analyses provide unbiased estimates of how interventions will fair in the target population(s), enabling apples-to-apples comparisons of interventions even when two interventions have not been compared in a head-to-head trial. In addition, the target population can be defined as sub-populations (e.g., younger children with high illness severity, comorbidities), enabling evaluation of relevant interventions for that sub-population, effectively providing insight into the question of “what works for whom?”


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $317,635 )
2024	2024	EMMA PENDLETON BRADLEY HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Mental Health Research Grants	000	3	8/29/2024	NON-COMPETING CONTINUATION	$317,635
														Subtotal = $317,635

Issue Date FY: 2023 ( Subtotal = $346,897 )
2023	2023	BRADLEY EMMA PENDLETON HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Mental Health Research Grants	000	2	8/1/2023	NON-COMPETING CONTINUATION	$346,897
														Subtotal = $346,897

Issue Date FY: 2022 ( Subtotal = $488,971 )
2022	2022	BRADLEY EMMA PENDLETON HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Mental Health Research Grants	000	1	7/14/2022	NEW	$488,971
														Subtotal = $488,971

Grand Total All Awards = $1,153,503

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What works for Whom in Pediatric OCD

Award Number: R01MH128595

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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