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Mechanisms of Depression and Anhedonia in Adolescents: Linking Sleep Duration and Timing to Reward- and Stress-Related Brain Function

Award Number: R01MH126109
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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7. PROJECT SUMMARY/ABSTRACT The long-term objectives of this proposal are: 1) to evaluate a biobehavioral model of depressive symptoms and anhedonia in adolescents, and 2) to leverage sleep and circadian function to promote mental health. These objectives are consistent with two key priorities of the National Institute of Mental Health (NIMH): 1) identify mechanisms of psychopathology, and 2) improve prevention and treatment for psychopathology. The proposed model of depression posits that sleep duration and/or timing moderate the effects of stressful events on depressive symptoms and anhedonia by disrupting reward- and stress-related brain function. The research approach uses two complementary study designs to evaluate the proposed model: 1) an observational study (n=150) that assesses the degree to which short and late sleep predict reward- and stress-related brain function and depressive symptoms and anhedonia, and 2) an experimental study (n=100) that assesses the extent to which sleep duration and timing impact reward- and stress-related brain function and depressive symptoms and anhedonia. The sample includes high-school adolescents (14-19 years of age) with enhanced risk for depressive symptoms based on exposure to lifetime stressful events and current depressive symptoms. Recruitment will be stratified to include adolescents with short and late sleep (weekday sleep duration = 6 h & midpoint = 4 am; n=100) versus long and early sleep (weekday sleep duration = 8 h & midpoint = 2:30 am; n=50). Both studies include measurement of daily sleep and stressful events for 2 weeks; laboratory measures of reward- and stress-related brain function and sleep and circadian characteristics; self-report measures of lifetime stressful events; and self-report measures of depressive symptoms and anhedonia during daily and weekly monitoring. The experimental study includes random assignment of adolescents with short and late sleep from the observational study to 2 weeks of either: 1) 90 min extension and advance of sleep opportunity and timing (n=50); or 2) typical sleep opportunity and timing (n=50). This research approach is designed to accomplish three specific aims: 1) Evaluate the extent to which sleep duration and/or timing predict reward- and stress-related brain function, and moderate the effects of stressful life events; 2) Establish the extent to which sleep duration and/or timing impact reward- and stress-related brain function, and moderate the effects of stressful life events; and 3) Determine the extent to which changes in reward- or stress-related brain function mediate the associations between sleep duration and/or timing and later depressive symptoms and anhedonia. The investigative team has expertise in the etiology and prevention of depression in adolescents, including specific expertise in the impact of sleep and stressful life events on the stress and reward systems that contribute to depression and anhedonia. All four investigators are also licensed clinical psychologists who are committed to translating research on the mechanisms of psychopathology to preventative interventions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $665,085 )
2024	2024	UNIVERSITY OF OREGON	1776 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Mental Health Research Grants	000	3	2/8/2024	NON-COMPETING CONTINUATION	$665,085
														Subtotal = $665,085

Issue Date FY: 2023 ( Subtotal = $743,496 )
2023	2023	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Mental Health Research Grants	000	2	1/27/2023	NON-COMPETING CONTINUATION	$743,496
														Subtotal = $743,496

Issue Date FY: 2022 ( Subtotal = $763,714 )
2022	2022	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Mental Health Research Grants	000	1	2/10/2022	NEW	$689,720
2022	2022	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Mental Health Research Grants	001	1	6/27/2022	NEW	$73,994
														Subtotal = $763,714

Grand Total All Awards = $2,172,295

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Mechanisms of Depression and Anhedonia in Adolescents: Linking Sleep Duration and Timing to Reward- and Stress-Related Brain Function

Award Number: R01MH126109

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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