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CRCNS US-Israel Research Proposal: Computational Phenotyping of Decision Making in Adolescent Psychopathology

Award Number: R01MH125564
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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CRCNS US-Israel Research Proposal: Computational Phenotyping of Decision Making in Adolescent Psychopathology - Adolescence is characterized by changes in decision-making, accompanied by the progressive development of the prefrontal cortex and reconfiguration of brain networks that support goal-directed decision-making. Adolescence is also the typical age of clinical onset and peak prevalence for many forms of mental illness. Recent advances in computational modeling of cognitive processes have enabled the quantification of parameters that govern learning and decision and characterization of how they differ in mental illnesses. There are several differentiating properties of learning and decision making processes in the brain: learning can be model-free (based on past trial and error) vs. model-based (learning the structure of a task and computing a best course of action given that structure), Pavlovian (with innate sensitivities to different motivationally relevant outcomes) vs. instrumental (arbitrarily adaptive), and learning occurs from positive and negative consequences. Furthermore, responses can be biased toward action or inaction, and can be more or less exploratory (variable). We will use three reinforcement-learning tasks that, together with computational models, index these multiple differentiable features of learning and decision making, in order to jointly define an individual “computational phenotype” of learning and decision processes. In Aim 1 this computational phenotype will be defined in a large online sample age 10-25 in order to map changes in symptom dimensions across adolescent development. In Aim 2 we will use neuroimaging to characterize the relationship between decision-making phenotypes and neural connectivity in children, adolescents, and young adults. In Aim 3 we will characterize the relation between decision-making phenotypes and clinical symptomatology in a diagnostically heterogeneous sample of adolescents with generalized anxiety, depression, ADHD or OCD. Throughout, computational modeling of task behavior and self-reported symptom dimensions will build on state-of-the-art hierarchical modeling of multimodal and multi-task data. The research activities described in this proposal hold the potential to improve our understanding of the cognitive and neural mechanisms that underpin adolescent psychopathology, a question of broad societal impact given the prevalence and cost of mental illness, and the super-additive benefits of early detection and treatment.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $227,211 )
2024	2024	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Mental Health Research Grants	000	5	7/8/2024	NON-COMPETING CONTINUATION	$227,211
														Subtotal = $227,211

Issue Date FY: 2023 ( Subtotal = $227,172 )
2023	2023	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Mental Health Research Grants	000	4	6/29/2023	NON-COMPETING CONTINUATION	$227,172
														Subtotal = $227,172

Issue Date FY: 2022 ( Subtotal = $227,211 )
2022	2022	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Mental Health Research Grants	000	3	7/9/2022	NON-COMPETING CONTINUATION	$227,211
														Subtotal = $227,211

Issue Date FY: 2021 ( Subtotal = $277,048 )
2021	2021	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Mental Health Research Grants	000	2	8/3/2021	NON-COMPETING CONTINUATION	$277,048
														Subtotal = $277,048

Issue Date FY: 2020 ( Subtotal = $305,207 )
2020	2020	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Mental Health Research Grants	000	1	8/14/2020	NEW	$305,207
														Subtotal = $305,207

Grand Total All Awards = $1,263,849

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CRCNS US-Israel Research Proposal: Computational Phenotyping of Decision Making in Adolescent Psychopathology

Award Number: R01MH125564

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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