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5/7 Psychiatric Genomics Consortium: Advancing Discovery and Impact

Award Number: R01MH124873
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/06/2021
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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5/7 Psychiatric Genomics Consortium: Advancing Discovery and Impact - Project Summary Now in its 13th year, the Psychiatric Genomics Consortium is perhaps the most innovative and productive experiment in the history of psychiatry. The PGC unified the field and attracted a cadre of outstanding scientists (802 investigators from 157 institutions in 41 countries). PGC work has led to identification of ~500 genetic loci in the 11 psychiatric disorders we study. Our work has led to 320 papers, many in high-profile journals (Nature 3, Cell 5, Science 2, Nat Genet 27, Nat Neurosci 9, Mol Psych 37, Biol Psych 25). As summary statistics are freely available, psychiatric disorders often feature prominently in papers by non-PGC investigators. To advance discovery and impact, we propose to continue the work of the PGC across 11 disorder groups. Considerable new data are coming in the next five years. We thus can rapidly and efficiently increase our knowledge of the fundamental basis of major psychiatric disorders. Aim 1: we will continue to advance genetic discovery for severe psychiatric disorders in all working groups, systematically interface with large biobank studies to ensure maximal comparability, and aggressively promote new studies of individuals with psychiatric disorders from diverse ancestries to increase discovery and improve fine-mapping. Aim 2: most studies analyze common variation (Aim 1), rare CNV (Aim 2), and rare exome/genome resequencing results (via collaboration) in isolation: we will apply an integrative framework to rigorously evaluate the contributions of all measured types of genetic variation on risk for psychiatric disorders. Aim 3: we will move beyond classical case-control definitions to a more biologically-based and nuanced understanding by enabling large trans-diagnostic studies, convene trans-disciplinary teams to use genetics to address unresolved questions about the nature of psychiatric disorders, and to promote large studies of the severest cases seen in psychiatric practice (leveraging the global reach of PGC investigators). Aim 4: we will work to maximize the impact of our work via translational efforts: close collaborations with neuroscience consortia to understand the biological implications of our findings; work to identify modifiable causal risk factors; and work to robustly predict clinical outcomes and identify patient subsets. Aim 5: we will increase impact of our work by extending and formalizing outreach to different communities (including pharma and biotech), via digital media (Twitter, Facebook, Wikipedia), and by developing, distributing, and updating resources/educational material for patients, families, and medical professionals. We will convene a Scientific Advisory Board to ensure we respond positively to those invested in our results Successful completion of this body of work will greatly advance knowledge of the genetic basis of psychiatric disorders with potentially major nosological and treatment implications. These goals are consistent with a core mission of the NIMH, and the central idea of the PGC: to convert the family history risk factor into biologically, clinically, and therapeutically meaningful insights.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$93,022 )
2026	2025	REDACTED DUE TO PII		CARDIFF				GBR	Mental Health Research Grants	000	5	8/17/2026	NON-COMPETING CONTINUATION	-$93,022
														Subtotal = -$93,022

Issue Date FY: 2025 ( Subtotal = $473,249 )
2025	2025	REDACTED DUE TO PII		CARDIFF				GBR	Mental Health Research Grants	000	5	4/12/2025	NON-COMPETING CONTINUATION	$473,249
														Subtotal = $473,249

Issue Date FY: 2024 ( Subtotal = $554,291 )
2024	2024	CARDIFF UNIVERSITY	30-36 NEWPORT ROAD	CARDIFF				GBR	Mental Health Research Grants	001	4	8/14/2024	NON-COMPETING CONTINUATION	$55,428
2024	2024	CARDIFF UNIVERSITY	30-36 NEWPORT ROAD	CARDIFF				GBR	Mental Health Research Grants	000	4	2/23/2024	NON-COMPETING CONTINUATION	$498,863
														Subtotal = $554,291

Issue Date FY: 2023 ( Subtotal = $499,416 )
2023	2023	CARDIFF UNIVERSITY	30-36 NEWPORT ROAD	CARDIFF				GBR	Mental Health Research Grants	000	3	2/22/2023	NON-COMPETING CONTINUATION	$499,416
														Subtotal = $499,416

Issue Date FY: 2022 ( Subtotal = $527,230 )
2022	2022	CARDIFF UNIVERSITY	30-36 NEWPORT ROAD	CARDIFF				GBR	Mental Health Research Grants	001	2	6/21/2022	NON-COMPETING CONTINUATION	$52,725
2022	2022	CARDIFF UNIVERSITY	30 36 NEWPORT ROAD	CARDIFF	SOUTH GLAMORGAN			GBR	Mental Health Research Grants	000	2	2/22/2022	NON-COMPETING CONTINUATION	$474,505
														Subtotal = $527,230

Issue Date FY: 2021 ( Subtotal = $561,638 )
2021	2021	CARDIFF UNIVERSITY	30 36 NEWPORT ROAD	CARDIFF	SOUTH GLAMORGAN			GBR	Mental Health Research Grants	001	1	5/20/2021	NEW	$61,236
2021	2021	CARDIFF UNIVERSITY	30 36 NEWPORT ROAD	CARDIFF	SOUTH GLAMORGAN			GBR	Mental Health Research Grants	000	1	4/6/2021	NEW	$500,402
														Subtotal = $561,638

Grand Total All Awards = $2,522,802

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5/7 Psychiatric Genomics Consortium: Advancing Discovery and Impact

Award Number: R01MH124873

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/06/2021

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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