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Dynamic Impacts of Sleep Disruption on Ecologically Assessed Affective, Behavioral, and Cognitive Risk Factors for Suicide

Award Number: R01MH124832
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2020
PERIOD OF PERFORMANCE END DATE: 10/31/2025

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Dynamic Impacts of Sleep Disruption on Ecologically Assessed Affective, Behavioral, and Cognitive Risk Factors for Suicide - Project Summary/Abstract Suicidal ideation and behavior are growing public health problems in the United States. Unfortunately, our current ability to predict suicide is only slightly above chance, which may be attributable to an overreliance on distal/cross-sectional risk factors that are weak proximal predictors of suicide risk. Modeling the complex process by which atypical sleep impacts daily functioning in conjunction with established proximal risk factors can aid in identifying contexts and time periods of greatest suicidal risk, modeled at the individual level. The proposed study builds upon our team’s extensive expertise in sleep/wake cycles, psychophysiology, deep phenotyping, and multi-method, multivariate, ecologically valid models of suicide vulnerability in high-risk psychiatric populations. We will examine how a holistic model of atypical sleep relates to known trait (baseline neurocognitive performance; e.g., greater impulsive tendencies, higher loss sensitivity, reduced ability to regulate emotions) and state (time-varying, occurring hours to days before SI/SB; e.g., momentary fluctuations in emotional reactivity, impulsivity; greater emotional lability; greater isolative tendencies), risk factors for suicide, and examine how these factors together proximally influence suicidal ideation and confer risk for future suicidal behavior. We will recruit 200 psychiatric inpatients at high risk for suicide and conduct a baseline assessment of sleep/wake functioning and trait risk factors and use laboratory-based tasks coupled with psychophysiology (i.e., event- related potentials, heart rate variability, and electrodermal activity) to phenotype risk processes linked to arousal and cognitive systems. This baseline assessment will be followed by four weeks of EMA and digital phenotyping coupled with SAFTE-derived actigraphy to characterize key state risk factors. We will conduct follow-up assessments at 1-, 3-, and 6-months post hospital discharge to determine how our proximal model of risk prospectively predicts SI and SB. The proposed study aims to characterize proximal risk for suicide using intensive longitudinal methods and to identify “windows” of greatest risk for suicide, which may vary from person to person, that serve as markers for intensive intervention. Finally, we will leverage this extensive dataset to develop a model of the sleep-suicide relationship emphasizing the contribution of trait and state factors. The results of this study have the potential to greatly enhance our understanding of the phenomenology of suicide risk as it exists in the real world, with the potential to improve our ability to predict, prevent, and intervene using both traditional and technology-enhanced psychotherapies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	BUTLER HOSPITAL	345 BLACKSTONE BLVD STE 2	PROVIDENCE	RI	02906	PROVIDENCE	USA	Mental Health Research Grants	000	4	10/22/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $520,422 )
2024	2024	BUTLER HOSPITAL	345 BLACKSTONE BLVD	PROVIDENCE	RI	02906	PROVIDENCE	USA	Mental Health Research Grants	000	4	10/30/2023	NON-COMPETING CONTINUATION	$468,381
2024	2024	BUTLER HOSPITAL	345 BLACKSTONE BLVD STE 2	PROVIDENCE	RI	02906	PROVIDENCE	USA	Mental Health Research Grants	001	4	6/4/2024	NON-COMPETING CONTINUATION	$52,041
														Subtotal = $520,422

Issue Date FY: 2023 ( Subtotal = $544,698 )
2023	2023	BUTLER HOSPITAL	345 BLACKSTONE BLVD	PROVIDENCE	RI	02906	PROVIDENCE	USA	Mental Health Research Grants	001	3	1/19/2023	NON-COMPETING CONTINUATION	$54,469
2023	2023	BUTLER HOSPITAL	345 BLACKSTONE BLVD	PROVIDENCE	RI	02906	PROVIDENCE	USA	Mental Health Research Grants	000	3	11/1/2022	NON-COMPETING CONTINUATION	$490,229
														Subtotal = $544,698

Issue Date FY: 2022 ( Subtotal = $552,455 )
2022	2022	BUTLER HOSPITAL	345 BLACKSTONE BLVD	PROVIDENCE	RI	02906	PROVIDENCE	USA	Mental Health Research Grants	000	2	10/25/2021	NON-COMPETING CONTINUATION	$497,210
2022	2022	BUTLER HOSPITAL	345 BLACKSTONE BLVD	PROVIDENCE	RI	02906	PROVIDENCE	USA	Mental Health Research Grants	001	2	6/21/2022	NON-COMPETING CONTINUATION	$55,245
														Subtotal = $552,455

Issue Date FY: 2021 ( Subtotal = $629,847 )
2021	2021	BUTLER HOSPITAL	345 BLACKSTONE BLVD	PROVIDENCE	RI	02906	PROVIDENCE	USA	Mental Health Research Grants	001	1	2/16/2021	NEW	$0
2021	2021	BUTLER HOSPITAL	345 BLACKSTONE BLVD	PROVIDENCE	RI	02906	PROVIDENCE	USA	Mental Health Research Grants	000	1	11/24/2020	NEW	$629,847
														Subtotal = $629,847

Grand Total All Awards = $2,247,422

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Dynamic Impacts of Sleep Disruption on Ecologically Assessed Affective, Behavioral, and Cognitive Risk Factors for Suicide

Award Number: R01MH124832

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2020

PERIOD OF PERFORMANCE END DATE: 10/31/2025

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