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Acute predictors of long-term post-trauma outcomes in youth victims of violence

Award Number: R01MH124076
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/13/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Acute predictors of long-term post-trauma outcomes in youth victims of violence - Youth violence victimization is common and increases risk for a host of negative health outcomes, most notably posttraumatic stress disorder (PTSD), which is the strongest predictor of poor quality of life following trauma, even among those injured during the event. Given the potential harmful sequelae of trauma exposure, it is crucial to identify acute post-victimization risk factors that predict chronic PTSD. At this juncture relatively little data exists to aid in prediction of youth at risk for poor long-term adjustment following victimization or other types of trauma, and there are no studies measuring relevant neural systems. Thus, our team aims to 1) characterize acute post-victimization neurobehavioral predictors of risk for chronic PTSD with a focus on prefrontal-subcortical function during processing of threat processing and frontoparietal networks for cognitive control, and 2) use machine learning to identify the most robust set of predictors of chronic PTSD drawn from a comprehensive assessment of youth neuroimaging, behavior and self-report, parent and family factors, and neighborhood and community variables. Our team is well-prepared to successfully achieve these aims, as we have relevant expertise in conducting prospective longitudinal assessment of acute neurobehavioral predictors of risk for PTSD in adults (Larson), conducting longitudinal assessment of youth victims of violence (Levas), and longitudinally characterizing neurobehavioral profiles of youth PTSD (Herringa). We will recruit youth victims of violence aged 10-16 from the Emergency Department at Children’s Hospital of Wisconsin in Milwaukee, and conduct comprehensive assessments at 2 weeks, 3 months, and 12 months following victimization. To achieve a final sample of 200 youth at 12 month follow-up, we will recruit 240 youth, oversampled for risk for PTSD based on currently available brief self-report indicators. Each assessment will include measures of neural systems instantiating threat processing, including both reactivity to threat and anticipation of unpredictable and predictable threat, and cognitive control, along with measures of PTSD and other symptoms, cognitive functioning, family environment, social and school functioning, and socioenvironmental factors (e.g. neighborhood disadvantage, discrimination). We will examine how acute post- victimization variables (2 week) and early change following victimization (from 2 weeks to 3 months) predict PTSD and other outcomes twelve months later. We will use both hypothesis-driven analyses focusing on a priori specified regions and predictors, as well as comprehensive data-driven machine learning analyses. The comprehensive assessment will allow for determination of the additional utility of neural markers for predicting risk beyond previously identified self-report indicators. We expect this project to lead to identification of predictors of risk for PTSD following victimization that are linked to underlying processes (hyper-responsivity to threat, aberrant cognitive control) that can directly inform preventive interventions, ultimately improving the quality of life for youth victims of violence.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF WISCONSIN SYSTEM	3203 N DOWNER AVE # 273	MILWAUKEE	WI	53211	MILWAUKEE	USA	Mental Health Research Grants	000	5	4/21/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $288,194 )
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	3203 N DOWNER AVE # 273	MILWAUKEE	WI	53211	MILWAUKEE	USA	Mental Health Research Grants	000	5	8/20/2024	NON-COMPETING CONTINUATION	$288,194
														Subtotal = $288,194

Issue Date FY: 2023 ( Subtotal = $690,897 )
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	3203 N DOWNER AVE	MILWAUKEE	WI	53211	MILWAUKEE	USA	Mental Health Research Grants	000	4	6/1/2023	NON-COMPETING CONTINUATION	$690,897
														Subtotal = $690,897

Issue Date FY: 2022 ( Subtotal = $702,165 )
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	3203 N DOWNER AVE STE 273	MILWAUKEE	WI	53211	MILWAUKEE	USA	Mental Health Research Grants	001	3	8/25/2022	NON-COMPETING CONTINUATION	$702,165
2022	2021	UNIVERSITY OF WISCONSIN SYSTEM	3203 N DOWNER AVE STE 273	MILWAUKEE	WI	53211	MILWAUKEE	USA	Mental Health Research Grants	000	2	8/19/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $702,165

Issue Date FY: 2021 ( Subtotal = $714,526 )
2021	2021	UNIVERSITY OF WISCONSIN SYSTEM	3203 N DOWNER AVE STE 273	MILWAUKEE	WI	53211	MILWAUKEE	USA	Mental Health Research Grants	000	2	6/30/2021	NON-COMPETING CONTINUATION	$714,526
														Subtotal = $714,526

Issue Date FY: 2020 ( Subtotal = $768,281 )
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	3203 N DOWNER AVE STE 273	MILWAUKEE	WI	53211	MILWAUKEE	USA	Mental Health Research Grants	001	1	9/16/2020	NEW	$0
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	3203 N DOWNER AVE STE 273	MILWAUKEE	WI	53211	MILWAUKEE	USA	Mental Health Research Grants	000	1	8/13/2020	NEW	$768,281
														Subtotal = $768,281

Grand Total All Awards = $3,164,063

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Acute predictors of long-term post-trauma outcomes in youth victims of violence

Award Number: R01MH124076

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/13/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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