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Data-driven solutions for temporal, spatial, and spatiotemporal dynamic functional connectivity

Award Number: R01MH123610
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/19/2021
PERIOD OF PERFORMANCE END DATE: 01/31/2026

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Data-driven solutions for temporal, spatial, and spatiotemporal dynamic functional connectivity - Project Summary/Abstract Existing approaches to estimate and characterize whole brain time-varying connectivity from fMRI data have shown considerable promise, with exponential growth in research in this field. We and others have developed a powerful set of tools that are now in wide use in the community. However, the impact of mental illness on brain connectivity is complex, and as we show, limitations in existing methods often result in missing important features associated with brain disorders (e.g. transient fractionation of the spatial structure of brain networks). Some of these important limitations include 1) the most widely-used approaches often require a number of prior and limiting assumptions that are not well studied, 2) methods often assume linear relationships either within or between networks over time, and 3) methods assume spatially fixed nodes and ignore the possibility of spatially fluid evolution of networks over time. We propose a novel family of models that builds on the well-structured framework of joint blind source separation to capture a more complete characterization of (potentially nonlinear) spatio-temporal dynamics while providing a way to relax other limiting assumptions. Our models will also produce a rich set of metrics to characterize the available dynamics and enable in depth comparison with currently avail- able models including those that are model based. We will extensively validate our approaches in a variety of ways including simulations and evaluation of rigor and robustness in large normative data sets. Finally, we will apply the developed tools to study the important area of dynamic properties in mental illnesses including schiz- ophrenia, bipolar disorder, and the autism spectrum. There is considerable evidence of disruption of dynamics in all three disorders, and as we show the use of static (or even exiting dynamic) approaches can miss important information about brain related differences associated with each. We will provide open source tools and release data throughout the duration of the project via a web portal and the NITRC repository, hence enabling other investigators to use our approaches and compare their own methods with our own. Our tools have wide appli- cation to the study of the healthy brain as well as many other diseases such as Alzheimer's disease and attention deficit hyperactivity disorder. 38


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $561,985 )
2025	2025	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Mental Health Research Grants	000	5	5/8/2025	NON-COMPETING CONTINUATION	$561,985
														Subtotal = $561,985

Issue Date FY: 2024 ( Subtotal = $661,158 )
2024	2024	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Mental Health Research Grants	002	4	7/30/2024	NON-COMPETING CONTINUATION	$0
2024	2024	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Mental Health Research Grants	001	4	7/9/2024	NON-COMPETING CONTINUATION	$66,115
2024	2024	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Mental Health Research Grants	000	4	1/25/2024	NON-COMPETING CONTINUATION	$595,043
														Subtotal = $661,158

Issue Date FY: 2023 ( Subtotal = $595,044 )
2023	2023	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Mental Health Research Grants	000	3	2/7/2023	NON-COMPETING CONTINUATION	$595,044
														Subtotal = $595,044

Issue Date FY: 2022 ( Subtotal = $630,935 )
2022	2022	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Mental Health Research Grants	000	2	1/31/2022	NON-COMPETING CONTINUATION	$567,841
2022	2022	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Mental Health Research Grants	001	2	6/7/2022	NON-COMPETING CONTINUATION	$63,094
														Subtotal = $630,935

Issue Date FY: 2021 ( Subtotal = $693,368 )
2021	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Mental Health Research Grants	001	1	5/12/2021	NEW	$67,940
2021	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Mental Health Research Grants	000	1	3/19/2021	NEW	$625,428
														Subtotal = $693,368

Grand Total All Awards = $3,142,490

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Data-driven solutions for temporal, spatial, and spatiotemporal dynamic functional connectivity

Award Number: R01MH123610

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/19/2021

PERIOD OF PERFORMANCE END DATE: 01/31/2026

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