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Social and structural violence and HIV care continuum outcomes: Developing a trauma-informed HIV care intervention among WLWH

Award Number: R01MH123349
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/15/2021
PERIOD OF PERFORMANCE END DATE: 03/20/2025

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Social and structural violence and HIV care continuum outcomes: Developing a trauma-informed HIV care intervention among WLWH - PROJECT SUMMARY/ABSTRACT We will use innovative social epidemiological methods to longitudinally characterize the impacts and mechanisms of gender-based violence on the HIV care continuum, define key components of differentiated HIV care models that mitigate these relationships and develop a platform for trauma- and violence-informed HIV care and practice (TVI-HCP) interventions, among cisgender (cis) and transgender (trans) women living with HIV (WLWH). Emerging evidence suggests that the COVID-19 pandemic has resulted in heightened social and structural gender-based violence against cis and trans women, who are shouldering an inequitable share of the resulting impact of restrictions, physical distancing and economic downtown. Impacts felt by marginalized cis and trans women, including WLWH, are even more severe and the short- and long-term consequences in terms of trauma, violence, safety and HIV care continuum outcomes of cis and trans WLWH will need to be addressed. Even prior to COVID-19 crisis, despite substantial programmatic advancements, WLWH experienced gaps relative to cisgender men in all global HIV targets in many settings. Although the global prevalence of social and structural violence by WLWH is alarmingly high, there is a lack of research delineating mechanisms through which different types of violence impact HIV care continuum outcomes, to inform intervention targets. Moreover, despite calls to apply a trauma-and violence-informed care approach to HIV care and practice (TVI-HCP) and the unique needs of WLWH, surprisingly little is known about how this approach can be tailored in HIV clinical practice environments. In the proposed study we will leverage an existing community-based cohort of cis and trans WLWH in a Canadian setting (Sexual Health and HIV/AIDS: Women's Longitudinal Needs Assessment) and recapture and expand this cohort to 300 WLWH in the City of Vancouver. This quantitative study will include survey interviews, innovative mapping and spatial analyses, HIV disease monitoring, and confidential administrative linkages to fill critical research gaps and inform components of multi-level TVI-HCP programming to optimize HIV care continuum outcomes by: (1) Prospectively characterizing relationships between different types of violence experiences (interpersonal emotional, physical and sexual violence; neighbourhood violence) and viral load suppression failure and identifying critical mediators in these relationships on which to intervene; (2) Prospectively characterizing the key components of differentiated HIV care models that have the strongest associations with viral load suppression, expanding on our preliminary development and validation of a TVI-HCP Scale for WLWH; and (3) Establishing an innovative social epidemiological platform for informing and evaluating future multi-level trauma- and violence-informed HIV care interventions. Amidst the ongoing COVID-19 crisis, in parallel with a syndemic of violence, trauma and HIV in North America, our study offers an unprecedented opportunity to inform differentiated HIV care models to optimize HIV clinical outcomes among marginalized women.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $401,871 )
2025	2025	THE UNIVERSITY OF BRITISH COLUMBIA	224-6328 MEMORIAL RD	VANCOUVER	BC			CAN	Mental Health Research Grants	001	5	3/20/2025	NON-COMPETING CONTINUATION	$0
2025	2025	THE UNIVERSITY OF BRITISH COLUMBIA	224-6328 MEMORIAL RD	VANCOUVER	BC			CAN	Mental Health Research Grants	000	5	12/12/2024	NON-COMPETING CONTINUATION	$401,871
														Subtotal = $401,871

Issue Date FY: 2024 ( Subtotal = $470,847 )
2024	2024	THE UNIVERSITY OF BRITISH COLUMBIA	224-6328 MEMORIAL RD	VANCOUVER	BC			CAN	Mental Health Research Grants	000	4	10/31/2023	NON-COMPETING CONTINUATION	$423,763
2024	2024	THE UNIVERSITY OF BRITISH COLUMBIA	224-6328 MEMORIAL RD	VANCOUVER	BC			CAN	Mental Health Research Grants	001	4	6/27/2024	NON-COMPETING CONTINUATION	$47,084
														Subtotal = $470,847

Issue Date FY: 2023 ( Subtotal = $468,903 )
2023	2023	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC			CAN	Mental Health Research Grants	000	3	11/8/2022	NON-COMPETING CONTINUATION	$422,013
2023	2023	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC			CAN	Mental Health Research Grants	001	3	1/23/2023	NON-COMPETING CONTINUATION	$46,890
														Subtotal = $468,903

Issue Date FY: 2022 ( Subtotal = $468,903 )
2022	2022	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC			CAN	Mental Health Research Grants	001	2	6/7/2022	NON-COMPETING CONTINUATION	$46,890
2022	2022	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC			CAN	Mental Health Research Grants	000	2	12/3/2021	NON-COMPETING CONTINUATION	$422,013
														Subtotal = $468,903

Issue Date FY: 2021 ( Subtotal = $478,234 )
2021	2021	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC			CAN	Mental Health Research Grants	000	1	1/12/2021	NEW	$478,234
														Subtotal = $478,234

Grand Total All Awards = $2,288,758

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Social and structural violence and HIV care continuum outcomes: Developing a trauma-informed HIV care intervention among WLWH

Award Number: R01MH123349

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/15/2021

PERIOD OF PERFORMANCE END DATE: 03/20/2025

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