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A comparison of environmental and genetic risks for schizophrenia and bipolar disorder: A Swedish national study

Award Number: R01MH122544
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract In this study we seek to understand how environmental factors influence the risk of developing schizophrenia (SZ) and bipolar disorder (BD) and how these risk factors interact with genetic risk for these disorders. SZ and BD are of major public health importance owing to their profound personal and societal costs. Major advances have been made in understanding the genetic architectures and specific loci conferring risk for these disorders individually and jointly. While robust, replicated findings for environmental risk factors for SZ have been identified, these have failed to materialize for BD. We intend to address to address this imbalance through parallel investigations of environmental risk for SZ and BD and explore possible interactions with genetic risk for these disorders. For this work, we will utilize data from the Swedish National Registers which contain data across the lifespan for the Swedish population (>10 million). Our first aim seeks to assess the impact of environmental risk factors on the development of SZ or BD and whether these are shared or divergent. These will include: urban living, infections, obstetric complications, migration, childhood adversity, cannabis use, and winter or spring birth. Additionally, an individual’s genes may differentially affect sensitivity to environmental exposures. Therefore, we will use both indirect (family history) and direct (molecular genetic) assessments of genetic risk for SZ and BD in relation to environmental exposures. Registry information available for this study is accurate and complete out to third degree relatives for total population measures of family history for these disorders (Aim 2). Existing molecular genetic data collected in Sweden for 10,059 SZ cases, 11,052 BD cases, and 22,138 controls will be used for analyses of directly measured genetic risk (Aim 3). Concurrent examination of BD and SZ will allow for direct comparisons of how environmental exposures act independently and in conjunction with genetic risk to shape these diagnoses. Elucidating the mechanisms which give rise to these related conditions may reveal opportunities for prevention efforts and therapeutic targets to ultimately reduce the personal and societal burdens of these devastating disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $283,669 )
2023	2023	KAROLINSKA INST	NOBELS VAG 6	SOLNA				SWE	Mental Health Research Grants	000	4	3/14/2023	NON-COMPETING CONTINUATION	$283,669
														Subtotal = $283,669

Issue Date FY: 2022 ( Subtotal = $295,396 )
2022	2022	KAROLINSKA INST	NOBELS VAG 6	SOLNA	STOCKHOLM			SWE	Mental Health Research Grants	001	3	6/6/2022	NON-COMPETING CONTINUATION	$29,542
2022	2022	KAROLINSKA INST	NOBELS VAG 6	SOLNA	STOCKHOLM			SWE	Mental Health Research Grants	000	3	2/22/2022	NON-COMPETING CONTINUATION	$265,854
														Subtotal = $295,396

Issue Date FY: 2021 ( Subtotal = $295,396 )
2021	2021	KAROLINSKA INST	NOBELS VAG 6	SOLNA	STOCKHOLM			SWE	Mental Health Research Grants	000	2	3/9/2021	NON-COMPETING CONTINUATION	$295,396
														Subtotal = $295,396

Issue Date FY: 2020 ( Subtotal = $318,304 )
2020	2020	KAROLINSKA INST	SOLNAVAGEN 1	SOLNA		17165		SWE	Mental Health Research Grants	000	1	5/18/2020	NEW	$318,304
														Subtotal = $318,304

Grand Total All Awards = $1,192,765

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A comparison of environmental and genetic risks for schizophrenia and bipolar disorder: A Swedish national study

Award Number: R01MH122544

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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