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The Role of Neuronal Ensembles Supporting Auditory Fear Conditioning (Engrams) in the Amygdala in Memory Formation, Generalization and Extinction

Award Number: R01MH119421
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Memory may be defined as the retention over time of internal representations gained through experience, and the capacity to reconstruct these representations at later times (Dudai 2007). These internal representations are thought to be encoded by long-lasting physical brain changes (memory traces or `engrams') (Josselyn, Kohler & Frankland 2015, 2017; Tonegawa et al. 2015; Schacter 2001). Remembering fear-evoking events is adaptive; it helps one make future choices based on past experience. It may even be beneficial to generalize some fearful memories. However, excessive fear generalization or treating no-longer threatening stimuli as dangerous may be maladaptive. Indeed, recurrent or inappropriately expressed fearful memories are a major component of several psychiatric diseases, including post-traumatic stress disorder (PTSD) and anxiety. Therefore, understanding how memory traces for fearful events are formed, change over time, under what conditions they remain specific or generalize, and how they are impacted by behavioral extinction are critical questions to not only understanding how the brain uses information but also for informing the development of new treatment/prevention strategies for disorders characterized by inappropriate fear memories. Here two PIs (Drs. Josselyn and Frankland), both New Investigators, will combine their expertise to address these important questions. Because all techniques are associated with caveats and limitations, we will use a variety of techniques including optogenetic manipulation, brain-wide neuronal activity mapping and the use of graph-theory to produce “engram maps” and real time in vivo calcium imaging combined with behavior. Together, the ability to manipulate and observe an engram as it forms, changes over time and with behavioral extinction is innovative and may lead to a shift in the very definition of an engram, as well as increase our understanding for developing treatments aimed at resolving inappropriate fear memories.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON			CAN	Mental Health Research Grants	000	5	6/12/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $337,780 )
2023	2023	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON			CAN	Mental Health Research Grants	000	5	1/27/2023	NON-COMPETING CONTINUATION	$337,780
														Subtotal = $337,780

Issue Date FY: 2022 ( Subtotal = $337,780 )
2022	2022	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON			CAN	Mental Health Research Grants	000	4	1/20/2022	NON-COMPETING CONTINUATION	$304,002
2022	2022	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON			CAN	Mental Health Research Grants	001	4	5/23/2022	NON-COMPETING CONTINUATION	$33,778
														Subtotal = $337,780

Issue Date FY: 2021 ( Subtotal = $337,780 )
2021	2021	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON			CAN	Mental Health Research Grants	000	3	1/28/2021	NON-COMPETING CONTINUATION	$337,780
														Subtotal = $337,780

Issue Date FY: 2020 ( Subtotal = $355,558 )
2020	2020	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON	M5G 1X8		CAN	Mental Health Research Grants	000	2	1/23/2020	NON-COMPETING CONTINUATION	$355,558
														Subtotal = $355,558

Issue Date FY: 2019 ( Subtotal = $355,558 )
2019	2019	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON	M5G 1X8		CAN	Mental Health Research Grants	001	1	9/24/2019	NEW	$0
2019	2019	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON	M5G 1X8		CAN	Mental Health Research Grants	000	1	3/11/2019	NEW	$355,558
														Subtotal = $355,558

Grand Total All Awards = $1,724,456

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The Role of Neuronal Ensembles Supporting Auditory Fear Conditioning (Engrams) in the Amygdala in Memory Formation, Generalization and Extinction

Award Number: R01MH119421

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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