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Cerebellar circuits, timing, and cognition

Award Number: R01MH118240
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2018
PERIOD OF PERFORMANCE END DATE: 11/30/2023

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Cerebellar circuits, timing, and cognition - ABSTRACT The cerebellum is densely connected to the cerebral cortex allowing it to powerfully modulate diverse cognitive networks. The specific mechanisms by which the cerebellum modulates the frontal cortex are unknown. In neuropsychiatric diseases such as schizophrenia and autism, deficits in working memory, attention, reasoning, and timing are accompanied by cerebellar abnormalities – both structural and functional. There are currently no effective treatments for cognitive dysfunction in neuropsychiatric disease. Understanding cerebellar modulation of frontal circuits may lead to novel treatments targeting the cerebellum for cognitive dysfunction in human disease. For instance, cerebellar transcranial magnetic stimulation has been effective in improving cognitive dysfunction in schizophrenia. Our goal is to understand how the cerebellum encodes timing for key cognitive events in order to understand how cerebellar stimulation influences cognition and frontal cortical activity. We will determine the lateral cerebellar nuclear and cerebellar cortical contribution to timing of key cognitive events by investigating how these regions encode time-dependent neuronal activity. We will determine if cerebellar stimulation can correct dysfunctional frontal cortical activity, rescuing timing and cognitive performance. Additionally, we will characterize long-term changes to performance, frontal cortical plasticity, and cerebellar-frontal circuitry. Results from the proposed experiments will provide fundamental mechanistic insight into the role of the cerebellum in cognition and may advance cerebellar stimulation as a therapy for schizophrenia and other brain diseases. !


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$5,387 )
2024	2023	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Mental Health Research Grants	000	5	4/12/2024	NON-COMPETING CONTINUATION	-$5,387
														Subtotal = -$5,387

Issue Date FY: 2023 ( Subtotal = $376,050 )
2023	2023	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Mental Health Research Grants	001	5	3/1/2023	NON-COMPETING CONTINUATION	$37,604
2023	2023	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Mental Health Research Grants	000	5	11/22/2022	NON-COMPETING CONTINUATION	$338,446
														Subtotal = $376,050

Issue Date FY: 2022 ( Subtotal = $382,006 )
2022	2022	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Mental Health Research Grants	001	4	5/16/2022	NON-COMPETING CONTINUATION	$38,202
2022	2022	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Mental Health Research Grants	000	4	12/6/2021	NON-COMPETING CONTINUATION	$343,804
														Subtotal = $382,006

Issue Date FY: 2021 ( Subtotal = $446,187 )
2021	2021	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Mental Health Research Grants	000	3	12/15/2020	NON-COMPETING CONTINUATION	$401,568
2021	2021	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Mental Health Research Grants	001	3	6/9/2021	NON-COMPETING CONTINUATION	$44,619
														Subtotal = $446,187

Issue Date FY: 2020 ( Subtotal = $525,538 )
2020	2020	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Mental Health Research Grants	001	2	3/11/2020	NON-COMPETING CONTINUATION	$46,281
2020	2020	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Mental Health Research Grants	002	2	8/20/2020	SUPPLEMENT FOR EXPANSION	$62,727
2020	2020	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Mental Health Research Grants	000	2	12/12/2019	NON-COMPETING CONTINUATION	$416,530
														Subtotal = $525,538

Issue Date FY: 2019 ( Subtotal = $438,167 )
2019	2019	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Mental Health Research Grants	000	1	11/21/2018	NEW	$438,167
2019	2019	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Mental Health Research Grants	001	1	9/25/2019	NEW	$0
														Subtotal = $438,167

Grand Total All Awards = $2,162,561

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Cerebellar circuits, timing, and cognition

Award Number: R01MH118240

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2018

PERIOD OF PERFORMANCE END DATE: 11/30/2023

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