Wednesday, January 15, 2025 1/15/2025

IMPlementation of evidence based facility and community interventions to reduce the treatment gap for depRESSion (IMPRESS)

Award Number: R01MH115504
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Depression is a leading cause of disability worldwide, and accounts for substantial morbidity, disability, and loss of productivity. Despite the availability of evidence based drug and psychological treatments for depression, the treatment gap in low and middle income countries (LMIC), including in India (the study setting), approaches 90%. Access to mental healthcare in LMICs remains limited due to both demand and supply side barriers such as lack of mental health professionals, low recognition rates of depression, stigma associated with mental disorders and the lack of contextualized evidence based psychosocial interventions. The goal of IMPRESS is to reduce the treatment gap for depression through the integrated implementation of evidence based interventions in facility and community platforms, in Goa, India. The project will evaluate, through an Effectiveness Implementation Hybrid cluster randomized controlled trial, the additional impact of an evidence based community intervention (“the Community Model”) to enhance the demand for, and improve the outcomes of, an evidence based, brief psychological treatment for depression (the Healthy Activity Program) delivered by non-specialist health workers in primary health care facilities (“the Facility Model”). Our hypothesis is that the Community Model will be superior to the purely Facility Model in: a) increasing the demand for depression treatment in primary care;; b) increasing uptake of treatment by patients with depression;; c) increasing treatment completion rates;; d) reducing symptoms of depression;; and being e) cost-effective. We will assess three specific mediation pathways for the additional impact of the community based interventions: improved mental health literacy in the community;; improved treatment adherence;; and increased patient-reported activation. Overall, the Community Model would be more effective and cost-effective in reducing the treatment gap for depression through an increase in ‘contact coverage’ (the proportion of affected individuals who seek help) and ‘effective coverage’ (the proportion of persons seeking care who ultimately derive the desired outcomes from the intervention). The proposal builds on a substantial body of evidence in the study settings, led by the program PIs, over the past two decades. Its most innovative aspect is that it integrates two different platforms to address the global burden of depression, and in doing so attempts to tackle one of the major unanswered questions in global mental health i.e. the coordination between community and primary care based approaches to reduce the treatment gap for depression.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $430,295 )
2024	2024	LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE	KEPPEL STREET	LONDON				GBR	Mental Health Research Grants	000	4	5/15/2024	NON-COMPETING CONTINUATION	$430,295
														Subtotal = $430,295

Issue Date FY: 2023 ( Subtotal = $449,094 )
2023	2023	LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE	KEPPEL STREET	LONDON				GBR	Mental Health Research Grants	000	3	5/16/2023	NON-COMPETING CONTINUATION	$449,094
														Subtotal = $449,094

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE	KEPPEL ST	LONDON				GBR	Mental Health Research Grants	000	2	8/24/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE	KEPPEL ST	LONDON				GBR	Mental Health Research Grants	000	2	7/16/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $484,456 )
2020	2019	LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE	KEPPEL ST	LONDON		WC1E 7HT		GBR	Mental Health Research Grants	004	2	6/1/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2020	2019	LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE	KEPPEL ST	LONDON		WC1E 7HT		GBR	Mental Health Research Grants	003	2	4/6/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2020	2019	LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE	KEPPEL ST	LONDON		WC1E 7HT		GBR	Mental Health Research Grants	001	2	11/20/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2020	2019	LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE	KEPPEL ST	LONDON		WC1E 7HT		GBR	Mental Health Research Grants	002	2	11/20/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$484,456
2020	2019	LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE	KEPPEL ST	LONDON		WC1E 7HT		GBR	Mental Health Research Grants	000	2	11/6/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $484,456

Issue Date FY: 2019 ( Subtotal = $472,154 )
2019	2019	LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE	KEPPEL ST	LONDON		WC1E 7HT		GBR	Mental Health Research Grants	000	2	8/5/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$472,154
														Subtotal = $472,154

Grand Total All Awards = $1,835,999

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IMPlementation of evidence based facility and community interventions to reduce the treatment gap for depRESSion (IMPRESS)

Award Number: R01MH115504

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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