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Neuroimaging MAO-B in Medication Free and Treatment Resistant Major Depressive Disorder Using Novel MAO-B Tracer [11C]SL2511.88

Award Number: R01MH115014
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Monoamine oxidase B (MAO-B) is a highly abundant protein in the brain that generates oxidative stress, removes monoamines such as dopamine and norepinephrine that support normal mood, and influences the predisposition towards apoptosis. MAO-B levels and activity are highly correlated and increase after chronic stress hormone exposure. MAO-B activity is increased in rodent brain after chronic unpredictable stress, however, MAO-B has not been studied in the most common early onset (age<45 years) major depressive disorder (MDD). Using [11C]SL25.1188 positron emission tomography, we propose to study whether MAO-B VT is elevated in key brain regions in early onset MDD during medication free major depressive episodes; (MDE; n=31), and in medication free major depressive episodes with a history of treatment resistance (n=31) as well as age matched healthy controls (from n=46). The intention is to make a convincing case that MAO-B levels are frequently elevated in key affect modulating regions during MDE, especially treatment resistant MDE. Such results could be applied to develop strategies for matching MDE cases of elevated MAO-B level towards MAO-B inhibitor treatments in the clinic through identifying low cost predictors of elevated MAO-B level (such as the clinical and RDOC measures proposed and/or additional peripheral protein or genetic biomarkers in future study).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	CENTRE FOR ADDICTION AND MENTAL HEALTH	1001 QUEEN ST W	TORONTO	ON			CAN	Mental Health Research Grants	001	5	9/4/2024	NON-COMPETING CONTINUATION	$0
2024	2022	CENTRE FOR ADDICTION AND MENTAL HEALTH	1001 QUEEN ST W	TORONTO	ON			CAN	Mental Health Research Grants	000	5	10/31/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $210,223 )
2022	2022	CENTRE FOR ADDICTION AND MENTAL HEALTH	1001 QUEEN ST W	TORONTO	ON			CAN	Mental Health Research Grants	001	5	3/22/2022	NON-COMPETING CONTINUATION	$0
2022	2022	CENTRE FOR ADDICTION AND MENTAL HEALTH	1001 QUEEN ST W	TORONTO	ON			CAN	Mental Health Research Grants	000	5	12/13/2021	NON-COMPETING CONTINUATION	$189,202
2022	2022	CENTRE FOR ADDICTION AND MENTAL HEALTH	1001 QUEEN ST W	TORONTO	ON			CAN	Mental Health Research Grants	002	5	5/13/2022	NON-COMPETING CONTINUATION	$21,021
														Subtotal = $210,223

Issue Date FY: 2021 ( Subtotal = $230,922 )
2021	2021	CENTRE FOR ADDICTION AND MENTAL HEALTH	1001 QUEEN ST W	TORONTO	ON			CAN	Mental Health Research Grants	001	4	4/13/2021	NON-COMPETING CONTINUATION	$23,091
2021	2021	CENTRE FOR ADDICTION AND MENTAL HEALTH	1001 QUEEN ST W	TORONTO	ON			CAN	Mental Health Research Grants	000	4	11/2/2020	NON-COMPETING CONTINUATION	$207,831
														Subtotal = $230,922

Issue Date FY: 2020 ( Subtotal = $235,063 )
2020	2020	CENTRE FOR ADDICTION AND MENTAL HEALTH	1001 QUEEN ST W	TORONTO	ON	M6J 1H4		CAN	Mental Health Research Grants	001	3	2/3/2020	NON-COMPETING CONTINUATION	$23,507
2020	2020	CENTRE FOR ADDICTION AND MENTAL HEALTH	1001 QUEEN ST W	TORONTO	ON	M6J 1H4		CAN	Mental Health Research Grants	000	3	11/7/2019	NON-COMPETING CONTINUATION	$211,556
														Subtotal = $235,063

Issue Date FY: 2019 ( Subtotal = $235,063 )
2019	2019	CENTRE FOR ADDICTION AND MENTAL HEALTH	1001 QUEEN ST W	TORONTO	ON	M6J 1H4		CAN	Mental Health Research Grants	000	2	10/24/2018	NON-COMPETING CONTINUATION	$235,063
														Subtotal = $235,063

Issue Date FY: 2018 ( Subtotal = $247,433 )
2018	2018	CENTRE FOR ADDICTION AND MENTAL HEALTH	1001 QUEEN ST W	TORONTO	ON	M6J 1H4		CAN	Mental Health Research Grants	000	1	11/3/2017	NEW	$247,433
														Subtotal = $247,433

Grand Total All Awards = $1,158,704

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Neuroimaging MAO-B in Medication Free and Treatment Resistant Major Depressive Disorder Using Novel MAO-B Tracer [11C]SL2511.88

Award Number: R01MH115014

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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