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Biological Systems as Mediators of Bidirectional Influences on Anxiety Risk in the Mother-Child Dyad During Infancy

Award Number: R01MH113669
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Anxiety is one of the most prevalent and costly problems facing mothers and their young children. Theoretical models about the etiology of anxiety risk, reflecting bidirectional associations between mothers and offspring, have gone largely without direct empirical testing. This has left a critical gap in knowledge regarding the nature of familial risk that will be necessary for a full understanding of the etiology of anxiety problems, one of the most prevalent, pervasive, and costly public health concerns in the present day. Two specific barriers to the successful prevention and treatment of anxiety problems include (1) an absence of empirically validated models that elucidate bidirectional influences between mothers and children, and (2) a lack of knolwedge of the neurobiological mechanisms that may serve as mediators for the bidirectional transmission of anxiety risk in mothers and offspring. Results from this project will contribute to the scientific knowledge base of anxiety risk in children and mothers across infancy and toddlerhood. This projects adopts a unique longitudinal multi-trait, multi-method design to test three biological systems as mediators of bidirectional effects of anxiety risk in mother-child dyads between child ages 1 and 3 years. Multiple aspects of negative valence systems are used to represent risk for anxiety in both children and mothers, and multiple biological arousal and regulatory systems are studied as mechanisms. Consistent with an RDoC framework, the project adopts a dimensional approach and utilizes both targeted and general sampling methods. The work proposed uncludes simultaneously testing maternal-based effects on child anxiety risk and child-based effects on maternal postpartum anxiety symptoms (Aim 1). Neural and neuroendocrine function in mothers and children will be tested as systems through which anxiety risk may be transmitted within the dyad (Aim 2). Children and mothers will be assessed via observation and surveys for levels of anxiety risk (fear, worry, anxious behaviors) and anxiety (anxiety symptoms) at each of three time points (child age 1, 2, and 3 years). This model will allow for the analysis of both concurrent and longitudinal associations between mother and child anxiety risk while accounting for individual stability in these systems. Aim 2 tests biological systems of neural (EEG, ERP) and neuroendocrine (cortisol) reactivity as mediators of transactional links between maternal and infant anxiety risk. Results will not only empirically test long-standing theories of child development, but will also inform the timing and framework for future family-based interventions aimed at preventing or ameliorating long-term anxiety problems in both mothers and young children, aligning with the National Institute of Mental Health’s mission to chart trajectories of mental illness and inform their prevention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $276,051 )
2025	2025	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Mental Health Research Grants	000	4	1/7/2025	SUPPLEMENT FOR EXPANSION	$276,051
														Subtotal = $276,051

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Mental Health Research Grants	000	4	7/3/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $602,884 )
2023	2023	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Mental Health Research Grants	000	4	5/30/2023	NON-COMPETING CONTINUATION	$602,884
														Subtotal = $602,884

Issue Date FY: 2022 ( Subtotal = $624,172 )
2022	2022	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Mental Health Research Grants	000	3	5/31/2022	NON-COMPETING CONTINUATION	$624,172
														Subtotal = $624,172

Issue Date FY: 2021 ( Subtotal = $466,494 )
2021	2021	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Mental Health Research Grants	000	2	6/3/2021	NON-COMPETING CONTINUATION	$466,494
														Subtotal = $466,494

Issue Date FY: 2020 ( Subtotal = $478,201 )
2020	2020	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Mental Health Research Grants	000	1	7/27/2020	NEW	$478,201
														Subtotal = $478,201

Grand Total All Awards = $2,447,802

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Biological Systems as Mediators of Bidirectional Influences on Anxiety Risk in the Mother-Child Dyad During Infancy

Award Number: R01MH113669

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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